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What is metabolism?
The sum of all chemical reactions in the body
Which of the following are energy sources?
Carbohydrates, fats, proteins, and alcohol
Which organ is the primary site of metabolism?
Liver
What do muscle cells primarily store and use for energy?
Glycogen
The brain and central nervous system primarily depend on which energy source?
Glucose
Where does glycolysis occur?
Cytoplasm
Where does fatty acid oxidation take place?
Mitochondria
What is the end product of glycolysis under aerobic conditions?
Acetyl CoA
What happens to excess Acetyl CoA when energy demand is low?
Converted into fatty acids and stored as fat
What happens to proteins during metabolism?
They are broken down into amino acids, which enter different metabolic pathways
What does ATP stand for?
Adenosine Triphosphate
How is ATP formed from ADP?
By adding a phosphate group
Which process generates the most ATP?
Electron Transport Chain
What is the primary function of ATP?
Store and transfer energy
ATP provides energy for which of the following?
All of the above
Which process builds complex molecules using energy?
Anabolism
Which of the following is a catabolic reaction?
Glycolysis
What happens in a catabolic state?
The body breaks down molecules to produce energy
Which condition is associated with increased catabolism?
Degenerative diseases like cancer and HIV
Which of the following is an anabolic process?
Glycogen synthesis
What is the first step of carbohydrate metabolism?
Glycolysis
Mitochondria
Fatty acids are broken down into Acetyl CoA in mitochondria.
Low oxygen availability
Lactic acid is formed. Without oxygen, pyruvate is converted into lactic acid.
Deamination
Remove nitrogen from amino acids. Deamination removes nitrogen so that amino acids can enter metabolism.
TCA Cycle
The TCA cycle produces energy through oxidation of Acetyl CoA.
Acetyl CoA
Enter the TCA cycle to produce ATP. Acetyl CoA is a key intermediate in energy production.
Excess Acetyl CoA
Converted into fat. When energy needs are met, Acetyl CoA is stored as fat.
NADH
NADH carries electrons to the Electron Transport Chain.
Electron Transport Chain
The primary site of ATP production.
Energy surplus
Excess energy is stored as fat. The body stores excess energy for future use.
Carbohydrates during feasting
Stored as glycogen, then converted to fat if excess. The body first stores carbohydrates as glycogen, but excess is turned into fat.
Excess dietary fat storage
Directly as fat. Unlike carbohydrates, fats do not need conversion and are stored directly.
Protein in excess
Used for body needs first, then stored as fat. Protein is used for repair and maintenance before being converted to fat.
Primary fuel source in fasting
Glycogen stores. Glycogen is the first energy reserve used when food is unavailable.
Metabolic change after 24 hours of fasting
Fat breakdown increases, and ketones are produced. The body begins breaking down fat for energy, producing ketones.
Purpose of ketosis
Provide an alternative energy source to glucose. Ketones serve as a backup fuel for the brain when glucose is low.
Muscle tissue during prolonged fasting
Protein is broken down for glucose. When glycogen is depleted, the body starts breaking down muscle for energy.
Risk of prolonged fasting
Slow metabolism and muscle loss. Long-term fasting reduces muscle mass and lowers metabolic rate.
Fasting and the immune system
Weakens it due to lack of nutrients. Without essential nutrients, immune function declines.
Ketosis as a long-term energy source
Can lead to nutrient deficiencies and cognitive issues. Ketosis is a survival mechanism, not a sustainable energy system.
Alcohol metabolism
Liver. The liver processes alcohol and converts it into Acetyl CoA.
Alcohol intake exceeds liver capacity
Alcohol remains in the bloodstream, causing intoxication. The liver can only process a certain amount at a time.
Alcohol
Remains in the bloodstream, causing intoxication.
Acetaldehyde
A harmful byproduct of alcohol metabolism that is toxic and contributes to hangover symptoms.
NADH levels
Increases NADH, preventing Acetyl CoA from entering the TCA cycle, disrupting normal metabolism and leading to fat accumulation.
Fatty liver disease
A long-term effect of excessive alcohol consumption, where chronic alcohol use leads to fat buildup in the liver.
Abdominal fat storage
Increases due to excess alcohol, which is linked to increased fat deposits in the abdomen.
Dehydration caused by alcohol
Alcohol inhibits the release of antidiuretic hormone (ADH), leading to excessive urination and dehydration.
Calories in alcohol
Alcohol provides 7 kcal per gram, but it is not a nutrient.
Empty calories
Alcohol is considered 'empty calories' because it provides energy but lacks essential nutrients.
Fat metabolism
Slows down due to the body's prioritization of alcohol metabolism, delaying fat breakdown.
ATP
The body's main energy currency used for energy transfer.
Excess energy intake
Stored as fat, regardless of source.
Basal Metabolic Rate (BMR)
The energy used at rest for basic functions, accounting for most of the body's energy use.
Lean muscle mass
The factor that most influences BMR, as more muscle increases energy expenditure at rest.
Thermic Effect of Food (TEF)
Energy used for digestion and absorption, accounting for 5-15% of daily energy use.
Macronutrient with highest TEF
Protein, which requires more energy to digest than fats or carbohydrates.
Calories in 1 pound of fat
3,500 kcal; a daily 500 kcal deficit leads to 1 pound of fat loss per week.
Weight maintenance
Mainly influenced by caloric balance (intake vs. expenditure); to maintain weight, calories in must equal calories out.
Non-Exercise Activity Thermogenesis (NEAT)
Increased by activities such as walking and fidgeting, including all non-exercise physical activity.
Sleep and metabolism
BMR is lowest during sleep; metabolism slows down at rest, but sleep is essential for regulation.
Body fat percentage
A more accurate measure of health than BMI, as BMI does not distinguish between fat and muscle.
Body fat distribution
Apple shape (central obesity) is most associated with health risks, increasing risks of diabetes and heart disease.
Waist circumference
A larger waist indicates higher risk of metabolic diseases, helping predict health risks beyond BMI.
Gender and body fat percentage
Women naturally have a higher body fat percentage, requiring more fat for reproductive functions.
Health risk of too little body fat
Hormonal imbalances and infertility can occur due to low fat levels disrupting hormone production.
Which measurement technique is most accurate for body fat percentage?
c) DEXA scan
Why can BMI misclassify individuals?
a) It does not account for muscle mass
What body fat percentage is considered obese for men?
c) 25% or higher
How can body composition be improved?
b) Increase muscle while decreasing fat
What is a consequence of visceral fat accumulation?
c) Increased risk of cardiovascular disease
Convert 150 pounds to kilograms. (1 lb = 0.4536 kg)
a) 60.8 kg
If a person weighs 62.7 kg, what is their BMR (for a woman)?
a) 1,354 kcal/day
Calculate the daily calorie deficit needed to lose 1 lb per week.
a) 500 kcal
How many grams of protein would you consume if you eat 6 oz of chicken (1 oz = 28.35 g, 1 oz of chicken = 7 g protein)?
a) 42 g
Convert 200 kcal to joules. (1 kcal = 4.184 kJ)
a) 836.8 kJ
Sarah's maintenance calorie requirement is 2,400 calories per day. She wants to lose 1 pound per week. What should her new daily calorie intake be?
a. 1,900
John currently consumes 3,200 calories per day to maintain his weight. He aims to lose 2 pounds per week. What is his target daily calorie intake?
b. 2,200
Tom needs 2,600 calories to maintain his weight. If he wants to lose 1 pound per week, what should his daily calorie intake be?
c. 2,100
Emily wants to lose 2 pounds per week. Her daily maintenance intake is 2,000 calories. What should her new daily intake be?
a. 1,000
Chris is eating 2,500 calories daily to maintain his current weight. He wants to lose 1 pound per week. How many calories should he consume per day?
b. 2,000