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1492
Christopher Columbus (Italian, in the service of the Spanish monarchy) sails to the New World, beginning an era of European colonization of the Americas.
1498
Vasco de Gama (Portugal) sails to India
1517
Martin Luther challenges Roman Catholic beliefs and practices (believed in authority of the bible over the pope / no indulgences); initiates Protestant Reformation
1521
Spanish forces, led by Hernán Cortés, defeat the Mexica people, led by Montezuma
1530
John Calvin breaks from the Catholic Church
1532
Spanish forces, led by Francisco Pizarro, defeat the Inca people
1542
Bartolomé de Las Casas writes A Short Account of the Destruction of the Indies
1549
The repartimiento reforms begin to replace the encomienda system
1587
Founding of the “lost” English colony of Roanoke
1588
English defeat of the Spanish Armada
1597
Juanillo’s Revolt in Florida (Natives against Spanish colonialism)
1598
Acoma Pueblo Massacre in New Mexico