isolated mutants and genes of C. elegans

lin-3

mutation:

phenotypes:

gene product (protein):

mutation: null (loss of function)

phenotypes: vulvaless (vul)

gene product (protein): epidermal growth factor (EGF)

let-23-

mutation:

phenotypes:

gene product (protein):

mutation: null (loss-of-function)

phenotypes: vulvaless

gene product (protein): EGF receptor

let-23D (dominant)

mutation:

phenotypes:

gene product (protein):

mutation: hypermorph (gain-of-function)

phenotypes: multivulva (Muv)

gene product (protein): EGFR

let-60-

mutation:

phenotypes:

gene product (protein):

mutation: null (loss-of-function:lf)

phenotypes: vulvaless

gene product (protein): RAS GTPase

let-60D (dominant)

mutation:

phenotypes:

gene product (protein):

mutation: hypermorph (gain-of-function: gf)

phenotypes: multivulva (Muv)

gene product (protein): RAS GTPase

lin-45

mutation:

phenotypes:

gene product (protein):

mutation: null (loss-of-function)

phenotypes: vulvaless (vul)

gene product (protein): RAF

mpk-1

mutation:

phenotypes:

gene product (protein):

mutation: null (loss of function: lf)

phenotypes: vulvaless (vul)

gene product (protein): MAPK

lin-1D

mutation:

phenotypes:

gene product (protein):

mutation: hypermorph (gain-of-function: gf)

phenotypes: vulvaless

gene product (protein): ETS family TF

lin-1-

mutation:

phenotypes:

gene product (protein):

mutation: null (loss-of-function: lf)

phenotypes: multivulva (Muv)

gene product (protein): ETS family TF

what would be the phenotype of lin-3 (lf); let-60 (gf)

multivulva

(because let-60 is downstream of lin-3 - so it overrides the phenotype of lin-3)

what would be the phenotype of let-60 (gf); lin-45 (lf)

vulvaless

What would be the phenotype of let-60 (lf); lin-1 (lf)

multivulva

what would be the phenotype of let-60 (gf); lin-1 (gf)

vulvaless

what would be the phenotype of let-60 (gf); lin-45 (lf)

vulvaless

what would be the phenotype of lin-45(lf); lin-1(lf)

multivulva