Review Session Practice Questions

Which of the following is an advantage of suspensions?

Improved bioavailability of poorly soluble drugs

Which if the following parameters is not a factor in Stokes’ law for sedimentation rate?

Temperature of the medium

Measurement of zeta potential is useful in determining which property of a liquid formulation?

Stability

Wetting agents are added to suspensions to:

Reduce surface tension between solid and liquid

What is one property of a suspension that is different from that of a solution or a colloid?

If left to rest, the particles of a suspension will settle out

Flocculated particles in the suspension have one of the following properties:

Repulsive forces between particles are appreciable

In thixotropic systems, the viscosity ____ upon shaking, but the system regains viscosity _____ upon standing

decreases; slowly

Fluidity is a term associated with newtonian fluids. An equivalent term in plastic flow fluids is:

Mobility

Flocculated suspensions exhibit the flow of a type:

Plastic

Kinematic viscosity is the ratio of dynamic viscosity to the _____

density of the fluid

According to Newton’s law of viscosity, “the shear stress in flowing fluid is ____ to the rate of shear”

directly proportional

What are the characteristics of the Plastic Flow Rheogram?

Curve does NOT pass through origin

Initially behaves like an elastic body

Fails to flow until it reaches Yield Value, f

What are the characteristics of the Pseudoplastic Flow Rheogram?

As shear stress increases, shear rate increases but is NOT linear

What are the characteristics of the Dilatant Flow Rheogram?

As shear stress increases, shear rate increases but is NOT linear

Shear rate increases, resistance to flow increases

Dilatant flow is characterized as the reverse phenomenon of

Pseudoplastic flow

Aspartame is an excipient with the following properties. Based on the following statements, pick the correct choice:

I. is an artificial sweetener

II. breaks down into 3 components: phenylalanine, aspartic acid, and methanol

III. discouraged in patients with PKU

True

What is the role of Talc in dusting powder?

Vehicle

What is the role of Mineral Oil in Cold Cream (external application)?

Emollient

Choose the correct match of excipients used in semisolid dosage form to their function.

Emollients — modify vehicle/skin characteristics to assist penetration of API through skin

Which type of sterile preparation is not permitted to contain antimicrobial preservatives?

Injectable preparations given in large volumes for blood replenishment of nutrients

Which taste is produced by the presence of anions and cations together?

Salty

Which of the following does contain color additives?

Cosmetics

Lyophilized units disintegrate faster than conventional tablets.

True

What is the role of lactose in capsule

Bulk diluent

What natural sweetener is appropriate for pediatric formulations?

Sorbitol

A reconstituted antibiotic forms a hard, non-redispersible cake after 5 days. Which excipient was likely inadequate?

Flocculating Agent

During compression, tablets adhere to punches. Which adjustment is most effective?

Add talc or increase lubricant

Case: Cough Syrup for a patient with PKU. The pharmacist must choose a sweetener. Which should be avoided?

Aspartame

Case: Spoilage in an Aqueous Cream. A patient reports foul odor and visible microbial growth in a cream stored in a warm bathroom. Which error most likely caused this failure?

Use of parabens at insufficient concentration

Case: Bitter Pediatric Antibiotic Suspension. A pharmacist is compounding an oral suspension with a strongly bitter API for a toddler. The child previously refused the medication. Which excipient change will MOST improve acceptance?

Add a fruit-flavor oil plus a high-intensity sweetener

The time required for the drug to lose 10% of its original concentration. Or its the time required for the drug to degrade to 90% of its original concentration is called Shelf-Life.

True

The purpose of accelerated stability studies is to

Both A and B

Predict shelf-life of a drug and study drug degradation at a faster pace