Type II hypersensitivity and Goodpasture syndrome

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4 Terms

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What causes tissue damage in Type II hypersensitivity?

Binding of IgG or IgM to cell-surface molecules, leading to complement activation or antibody-dependent cell-mediated cytotoxicity (ADCC).

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What is the mechanism of tissue damage in Goodpasture syndrome?

Autoantibodies recognize self-antigens in basement membranes of kidneys and lungs, activating complement and causing vasculitis and tissue destruction.

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How is Hashimoto disease similar to Type II hypersensitivity?

Autoantibodies target thyroid-specific proteins, causing destruction of thyroid cells through ADCC, similar to Type II hypersensitivity.

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