Type II hypersensitivity and Goodpasture syndrome
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Last updated 6:07 PM on 4/12/25
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4 Terms
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What causes tissue damage in Type II hypersensitivity?
Binding of IgG or IgM to cell-surface molecules, leading to complement activation or antibody-dependent cell-mediated cytotoxicity (ADCC).
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What is the mechanism of tissue damage in Goodpasture syndrome?
Autoantibodies recognize self-antigens in basement membranes of kidneys and lungs, activating complement and causing vasculitis and tissue destruction.
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How is Hashimoto disease similar to Type II hypersensitivity?
Autoantibodies target thyroid-specific proteins, causing destruction of thyroid cells through ADCC, similar to Type II hypersensitivity.
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