Pharmacokinetics and Pharmacody

What is pharmacodynamics?

how the drug effects the body

What do drug pharmacodynamics depend on?

the achieved concentration of the active compound and the target site… which depends on ADME

True or False: appropriate and accurate drug dosing in the ICU is crucial for therapeutic success

true

What are the three key factors of PKPD in critically ill patients?

1. multiple medications are often required to treat the underlying disorder and coexisting comorbidities → increases the risk of drug-drug interactions and adverse drug events

2. critical illness results in pathophysiologic changes that may modify the medications’ exposure

3. the use of organ support can contribute to inter and intra-patient variability in the drug’s pharmacokinetics (renal replacement therapy-RRT)

What is the bioavailability of intravenous medications?

100%

What is the concern with intravenous administration?

does not guarantee penetration of the drug into sites outside the circulatory system