WBC Exam - Myeloproliferative Neoplasms

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6 Terms

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Myeloproliferative Neoplasms (MPN)

<20% blasts = chronic

Pan hypercellularity of BM with dominance of one cell line —> BM fibrotic

Defect in HSC

2
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Chronic Myeloid Leukemia (CML)

Ph+ t(9:22), BCR/ABL1 —> abnormal tyrosine kinase activity

3
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Chronic Neutrophilic Leukemia (CNL)

Sustained neutrophilia with no monocytosis or basophilia

Mutation of CSF3R

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Essential Thrombocythemia (ET)

Megakaryocytic lineage predominates

Single JAK2 mutation

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Polycythemia vera (PV)

Primary: Homozygous JAK2 mutation

Hypersensitive to EPO, ILGF1, IL3

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Primary Myelofibrosis (PMF)

Megakaryocytes —> fibrosis

dacryocytes (tear drop cells)