MEDS301 - Week 8: Pharmacotherapy of GI and Respiratory Disorders

Phases of Digestion

Cephalic, Gastric, Intestinal,

Cephalic Phase

Sight, Smell, Taste, thought of food that stimulates the release of gastric juices

Gastric Phase

Stomach distends, more release of gastric juices

Intestinal Phase

absorption of nutrients through intestinal epithelium

Fats and Acids prevent the secretion of gastric juices

Microvilli

in the intestinal epithelium which are finger like projections made up of bundles of actin filaments

these increase intestinal surface area for absorption

Regulation of Gastric Function

what causes Peptic Ulcer 1

helicobacter pylori, long term uses of NSAIDs, hyperacidity, hyperchlorhydria

Symptoms of Peptic Ulcer 1

Periodic Pain, nausea, vomiting, loss of appetite, heartburn

Gastrointestinal Esophageal Reflux Disease (GERD)

Heart burn→regurgitation of digestive juices into the esophagus

caused by inappropriate constriction of the lower esophageal sphincter

GERD therapeutic indications

suppresses acid promotion

prevents erosion

provides symptomatic relief

Management of GI disorders(lifestyle changes)

stop smoking, avoid caffeine+alcohol, lose weight(if overweight), elevate head of the bed

Management of GI Disorders(therapeutic)

Antibiotic and Antiulcer drug therapies

Antiulcer drug action

reduces gastric acidity

enhances mucosal barrier defences

involves the use of antisecretory drugs and antacids

Antihistamines receptor antagonists