\- Vesicles “docked” near presynaptic membrane \n - Action potential at the terminal opens CA++ channels \n - CA++ ions open a fusion pore \n - Vesicles release transmitter into the synapse \n - Transmitter diffuses across gap to the postsynaptic membrane receptors
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\- Vesicles “docked” near __*?* __ \n *- Action potential at the* terminal opens CA++ channels \n - CA++ ions open a fusion pore \n - Vesicles release transmitter into the synapse \n - Transmitter diffuses across gap to the postsynaptic membrane receptors
presynaptic membrane
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\- Vesicles “docked” near presynaptic membrane \n - Action potential at the terminal opens __?__ \n - CA++ ions open a fusion pore \n - Vesicles release transmitter into the synapse \n - Transmitter diffuses across gap to the postsynaptic membrane receptors
CA++ channels
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\- Vesicles “docked” near presynaptic membrane \n - Action potential at the terminal opens CA++ channels \n - CA++ ions open a __ ? __ \n - Vesicles release transmitter into the synapse \n - Transmitter diffuses across gap to the postsynaptic membrane receptors
fusion pore
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\- Vesicles “docked” near presynaptic membrane \n - Action potential at the terminal opens CA++ channels \n - CA++ ions open a fusion pore \n - Vesicles release transmitter into the __ ? __ \n - Transmitter diffuses across gap to the postsynaptic membrane receptors
synapse
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\- Vesicles “docked” near presynaptic membrane \n - Action potential at the terminal opens CA++ channels \n - CA++ ions open a fusion pore \n - Vesicles release transmitter into the synapse \n - __ __?__ *diffuses across gap to the* __ ? receptors.
\- transmitter, postsynaptic membrane
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Postsynaptic Receptors
\- Neurotransmitter “binds” to post-synaptic \n receptors (“lock and key”) \n - Receptor activation opens ion channels \n - Ions enter, producing depolarization or \n hyperpolarization \n - Ions create a “post-synaptic potential”
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\- Neurotransmitter “binds” to __?_ (“lock and key”) \n - Receptor activation opens ion channels \n - Ions enter, producing depolarization or \n hyperpolarization \n - Ions create a “post-synaptic potential”
Postsynaptic receptors
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\- Neurotransmitter “binds” to post-synaptic receptors (“lock and key”) \n - Receptor activation opens __?_ \n - Ions enter, producing depolarization or hyperpolarization \n - Ions create a “post-synaptic potential”
ion channels
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\- Neurotransmitter “binds” to post-synaptic receptors (“lock and key”) \n - Receptor activation opens ion channels \n - Ions enter, producing __?_ or __?_ \n - Ions create a “post-synaptic potential”
depolarization or hyperpolarization
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\- Neurotransmitter “binds” to post-synaptic receptors (“lock and key”) \n - Receptor activation opens ion channels \n - Ions enter, producing depolarization or hyperpolarization \n - __?_ create a “__?_ potential”
* Ions, post-synaptic
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Postsynaptic receptors control ion channels in 2 ways:
* directly, indirectly
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Directly
(ionotropic receptors)
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Indirectly
using second messenger systems (metabotropic receptors)
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Ionotropic Receptors:
The ion channel opens when a molecule of neurotransmitter attaches to the binding site.
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Post syaptic Potentials (PSP)’s are either-
excitatory (EPSP) or inhibitory (IPSP)
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Opening NA+ ion channels is-
(EPSP) *Excitatory* post synaptic potential
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Opening Cl- ion channels is-
(IPSP) *Inhibitory* Post synaptic potential
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Termination of Synaptic Transmission is accomplished via:
Reuptake or Enzymatic deactivation
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Reuptake:
Molecules of a neurotransmitter that has been released into the synaptic cleft are transported back into the terminal button
(transmitter is transported back into the presynaptic neuron)
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Enzymatic deactivation:
an enzyme destroys the transmitter molecule
\- Acetylcholine (ACh) \n - AChE – enzyme, destroys ACh
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EPSP →
depolarization
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IPSP →
hyperpolarization
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Effects of excitation or inhibition on behavior?
Need details on the neural circuits to predict \n effects on behavior
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Excitation of excitatory neurons can →
increase behavior
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Excitation of inhibitory neurons can →
decrease behavior
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Inhibition of inhibitory neurons can →
increase behavior
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Autoreceptors are located
pre-synaptically
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Autoreceptors respond to the neuron’s __?_
OWN transmitter
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Autoreceptors regulate amount of __?_ a neuron __?_.