Antibody class switching

what determines the antibody antigentic specificity

the VL and VH domains

how many types of antibodies can each B-cell/plasma cell make at a time

ONE

how many light chain genes do we have/ how many heavy chain genes

2 light and 1 heavy

what segment does the heavy chain have that the light chain does not

diversity gene segment

when do Ig become functional genes

when they are rearranged

when do Ig get rearranged

during antigen independant differentiation of B-cells in the bone marrow

where do light chains and heavy chains come together

ER

where are the mRNAs translated on the chains

ER

antibody vs combinational diversity

antibody - V(D)J recombination

Combinational - combinations of heavy and light chains

What is junctional diversity

when nucleotides are added or removed at random VDJ sites

what Ig do Naive B-cells expressed

igM and IgD

What is the first Ig released in response to antigens

IgM

when a B-cell changes to secrete a diferent antibody what part of the chain is changed

the constant regions of the heavy chain

what does class switching not alter on the chain

light chain and VH domain

What changes the constant domain

class switchin g