cell membrane function
interact with outside world, transport
chromosomes and their genes function in cells
code information and translate instructions
mitochondria function
create energy
endoplasmic reticulum and Golgi bodies function
make protein machinery to do things
dysplasia
refers to changes in cell size, shape, uniformity, arrangement and structure
large nuclei are frequently present and the rate of mitosis in increased- meaning they are replicating faster than they should
atrophy
decrease in cellular size ex; dementia, muscle loss
hypertrophy
increase in cellular size
hyperplasia
increase in number of cells
metaplasia
replacement of one type of cell with another
cardiomyopathy
hypertrophy of heart tissue
breast tissue adaptation in puberty, pregnancy, and menopause
puberty - hyperplasia
pregnancy - hypertrophy
menopause - atrophy
cellular changes in dysplasia
large squamous cells with small nuclei
nucleus increasing in size and darkening in color
markedly enlarged and darkened nucleus with abnormal chromatin
anaplasia
describes cells that have lost the distinct characteristics which define them as particular tissue types
oxidative stress
exposure of cells to reactive oxygen species (ROS), toxic oxygen molecules (radicals) that are formed by the reaction between oxygen and water during mitochondrial respiration
can be increased in many conditions including aging, infection, use of drugs
ROS species include: superoxide, hydrogen peroxide
free radical injury
damage of DNA or RNA
oxidations of polyunsaturated fatty acids in lipids
oxidations of amino acids in proteins
damage to mitochondria
damages cells ability to function and replicate properly
results in inflammation
long term effects are heart disease, diabetes, cancer
hypoxic injury
single most common cause of cellular injury
results from decreased oxygen in air, loss of hemoglobin r decreased efficacy of hemoglobin, decreased RBC production etc.
ischemia
most common cause of hypoxia
ischemia - reperfusion injury
reoxygenation can cause damage
when you reflood the body with oxygen it can cause an excess of oxygen and create reactive oxygen species, cause increased intracellular calcium, inflammation, complement activation resulting in inflammation and damage
examples of immunologic and inflammatory injury
chrons, diabetes, rheumatoid arthritis
cellular accumulations
a manifestation of cellular injury caused by an infiltration of excess cellular products such as water, lipids, proteins
bruising
extravasated red cells (broken red cells accumulate in skin)
phagocytosis of red cells by macrophages causes colour change
hemosiderin and iron free pigments
necrosis
irreversible cell injury causing death - causes by hypoxic injury
coagulative hypoxic injury
in kidneys and heart-albumin becomes firm and tissue swells
liquefactive hypoxic injury
in glial cells and brain - enzymes in brain cells liquify cells and form cysts
apoptosis
cellular death caused by other cell processes besides hypoxia such as mitochondrial death
caseous hypoxic injury
from TB in lungs
fat hypoxic injury
lipases break down breast and pancreas tissue, combines with calcium and necrosis looks chalky and white
gangrenous hypoxic injury
severe blockage in lower leg arteries, skin breaks down, bacteria move in and tissue dies
gas gangrene hypoxic injury
caused by infection of tissue with clostridium species - anaerobic bacteria make enzymes that destroy tissue
pathophysiology of cardiac hypertrophy
can occur in right or left ventricle
increased pressure in pulmonary or systemic circulating
cardiac muscle becomes thickened and stiff as a result of increased myocardial cell size
lack of compliance results in lack of adequate filling and decreased cardiac output, heart would not be able to supply for larger oxygen demand in body
eventually results in heart failure
clinical manifestation in cardiac hypertrophy
dyspnea- trouble breathing
angina- heart pain
syncope - fainting
cardiac dysrhythmias - because heart is not perfused well
fatigue - from lack of oxygen
treatment of cardiac hypertrophy
surgical (septal myectomy)
drugs:
drugs that relax the ventricles (calcium channel blockers such as diltiazem)
drugs that reduce the workload of the heart (beta blockers such as metoprolol)
drugs decrease the pressure that the heart must pump against ( beta blockers such as propranolol)
nonpharmacologic - low level exercise, healthy weight, nutrition, reduce alcohol
acromegaly -cellular hyperplasia
hyperplasia resulting from excessive growth hormone stimulation
usually caused by a pituitary tumor ( adenoma )
GH binds to cell receptors and stimulates cell proliferation GH stimulates the IGF - 1 in the liver which promotes growth in bones, cartilage, soft tissues and organs
aging and altered cellular and tissue biology
systemic aging causes sarcopenia (loss of muscle) from atrophy and loss of cells
the cellular changes proceed slowly and in small increments
maintaining muscle strength and mobility is key to a long and healthy life
somatic death
death of entire person
their are many postmortem changes
algor mortis (decreased body temp), livor mortis (purple color from blood pooling), rigor mortis (acidic compounds build up in muscles causing stiffening), an postmortem autolysis (release of enzymes and petrification)