GIN Full Top 300

Lansoprazole brand

Prevacid

Lansoprazole class

PPI

Lansoprazole MOA

Inhibits gastric parietal cell hydrogen-potassium ATPase

Lansoprazole side effects

Headache, diarrhea, abdominal pain, nausea, flatulence, long term use can lead to osteoporosis

Lansoprazole dose

15-20 mg PO qD

Lansoprazole contraindications

Dexlansoprazole brand

Dexilant

Dexlansoprazole class

PPI

Dexlansoprazole MOA

Inhibits gastric parietal cell hydrogen-potassium ATPase

Dexlansoprazole side effects

Headache, diarrhea, abdominal pain, nausea, flatulence, increased risk of osteoporosis

Dexlansoprazole dose

Initial: 60 mg PO qD, maintenance: 30 mg PO qD

Dexlansoprazole contraindications

Pantoprazole brand

Protonix

Pantoprazole class

PPI

Pantoprazole MOA

Inhibits gastric parietal cell hydrogen-potassium ATPase

Pantoprazole side effects

Diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, vertigo, myalgia, long term use causes bone loss

Pantoprazole dose

20 mg PO/IV qD

Omeprazole brand

Prilosec

Omeprazole class

PPI

Omeprazole MOA

Inhibits gastric parietal cell hydrogen-potassium ATPase

Omeprazole side effects

Diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, rash, upper respiratory infection, long term use causes bone loss

Omeprazole dose

20 mg PO qD

Esomeprazole brand

Nexium

Esomeprazole class

PPI

Esomeprazole MOA

Inhibits gastric parietal cell hydrogen-potassium ATPase

Esomeprazole side effects

Diarrhea, headache, abdominal pain, nausea, vomiting, flatulence, dizziness, long term use causes bone loss

Esomeprazole dose

20-40 mg PO qD

Famotidine brand

Pepcid

Famotidine class

H2 antagonist

Famotidine MOA

Antagonizes H2 histamine receptors

Famotidine side effects

Dizziness, headache, taste changes, constipation, diarrhea

Famotidine dose

20-40 mg PO qD

Ibuprofen brand

Advil, Motrin

Ibuprofen class

NSAID

Ibuprofen MOA

Inhibits COX, reducing prostaglandin and thromboxane synthesis

Ibuprofen side effects

Dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity

Ibuprofen dose

300-800 mg TID or QID

Ibuprofen contraindications

ASA/NSAID induced asthma, 2nd/3rd trimester of pregnancy, CABG surgery

Ibuprofen BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, proliferation

Meloxicam brand

Mobic

Meloxicam class

NSAID

Meloxicam MOA

Inhibits COX, reducing prostaglandin and thromboxane synthesis

Meloxicam side effects

Dyspepsia, nausea, abdominal pain, dizziness, headache, rash, contipation, edema, GI bleed

Meloxicam dose

7.5-15 mg PO qD

Meloxicam contraindications

ASA/NSAID allergy, 2nd/3rd trimester of pregnancy

Meloxicam BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation

Naproxen brand

Naprosyn, Naprelan

Naproxen class

NSAID

Naproxen MOA

Inhibits COX, reducing prostaglandin and thromboxane synthesis

Naproxen side effects

Dyspepsia, nausea, abdominal pain, constipation, drowsiness, photosensitivity, GI bleed

Naproxen dose

IR/DR: 250-500 mg PO q12h, ER: 750-1000 mg PO qD

Naproxen contraindications

ASA/NSAID induced asthma, 2nd/3rd trimester of pregnancy, CABG surgery

Naproxen BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleeds, ulceration, and proliferation

Celecoxib brand

Celebrex

Celecoxib class

NSAID

Celecoxib MOA

Selectively inhibits COX-2, reducing prostaglandin synthesis

Celecoxib side effects

Headache, diarrhea, nausea, vomiting, peripheral edema, photosensitivity, GI bleed

Celecoxib dose

100-200 mg PO qD or BID

Celecoxib contraindications

Hypersensitivity to sulfonamides, 2nd/3rd trimester of pregnancy

Celecoxib BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, proliferation

Diclofenac brand

Voltaren, Cambia, Catafiam

Diclofenac class

NSAID

Diclofenac MOA

Inhibits COX, reducing prostaglandin and thromboxane synthesis

Diclofenac side effects

Dyspepsia, vomiting, headache, dizziness, rash, drowsiness, fluid retention, GI bleed

Diclofenac dose

DR: 50 mg PO BID or TID, ER: 100 mg PO qD

Diclofenac contraindications

ASA/NSAID allergy, 2nd/3rd trimester of pregnancy

Diclofenac BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation

Ketorolac brand

Toradol, Sprix

Ketorolac class

NSAID

Ketorolac MOA

Inhibits COX, reducing prostaglandin and thromboxane synthesis

Ketorolac side effects

GI bleed, perforation, ulcer, dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity

Ketorolac dose

10 mg PO q4-6h PRN

Ketorolac contraindications

Major surgery post-op, ASA/NSAID induced asthma, epidural or intrathecal use, CABG surgery

Ketorolac BBW

May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation; oral: up to 5 days treatment and only after parenteral use

Apixaban brand

Eliquis

Apixaban class

Factor Xa inhibitor, DOAC

Apixaban MOA

Factor Xa inhibitor, inhibiting blood coagulation

Apixaban side effects

Bleeding, anemia, nausea

Apixaban dose

5 mg PO BID

Apixaban contraindications

Pregnancy, active bleeding, unstable PE

Apixaban BBW

Increased risk when stopped too soon, risk of hematoma with epidural or spinal puncture

Dabigatran brand

Pradaxa

Dabigatran class

Anticoagulant, direct thrombin inhibitor

Dabigatran MOA

Directly inhibits thrombin

Dabigatran side effects

Dabigatran dose

150 mg PO BID

Dabigatran contraindications

Dabigatran BBW

Increased risk of thrombotic events with premature discontinuation

Heparin brand

Heparin

Heparin class

Anticoagulant

Heparin MOA

Activates antithrombin, which inhibits coagulation factors

Heparin side effects

Heparin dose

80 units/kg IV push followed by 18 units/kg/hr continuous infusion

Heparin contraindications

Severe thrombocytopenia, uncontrolled active bleeding, history of HIT

Heparin BBW

None

Warfarin brand

Coumadin, Jantoven

Warfarin class

Anticoagulant, vitamin K inhibitor

Warfarin MOA

Inhibits vitamin K dependent coagulation factor synthesis

Warfarin side effects

Bleeding, abdominal cramps/pain, nausea, vomiting, diarrhea, fatigue, headache, taste changes, edema

Warfarin dose

Individualized