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Lansoprazole brand
Prevacid
Lansoprazole class
PPI
Lansoprazole MOA
Inhibits gastric parietal cell hydrogen-potassium ATPase
Lansoprazole side effects
Headache, diarrhea, abdominal pain, nausea, flatulence, long term use can lead to osteoporosis
Lansoprazole dose
15-20 mg PO qD
Lansoprazole contraindications
Dexlansoprazole brand
Dexilant
Dexlansoprazole class
PPI
Dexlansoprazole MOA
Inhibits gastric parietal cell hydrogen-potassium ATPase
Dexlansoprazole side effects
Headache, diarrhea, abdominal pain, nausea, flatulence, increased risk of osteoporosis
Dexlansoprazole dose
Initial: 60 mg PO qD, maintenance: 30 mg PO qD
Dexlansoprazole contraindications
Pantoprazole brand
Protonix
Pantoprazole class
PPI
Pantoprazole MOA
Inhibits gastric parietal cell hydrogen-potassium ATPase
Pantoprazole side effects
Diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, vertigo, myalgia, long term use causes bone loss
Pantoprazole dose
20 mg PO/IV qD
Omeprazole brand
Prilosec
Omeprazole class
PPI
Omeprazole MOA
Inhibits gastric parietal cell hydrogen-potassium ATPase
Omeprazole side effects
Diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, rash, upper respiratory infection, long term use causes bone loss
Omeprazole dose
20 mg PO qD
Esomeprazole brand
Nexium
Esomeprazole class
PPI
Esomeprazole MOA
Inhibits gastric parietal cell hydrogen-potassium ATPase
Esomeprazole side effects
Diarrhea, headache, abdominal pain, nausea, vomiting, flatulence, dizziness, long term use causes bone loss
Esomeprazole dose
20-40 mg PO qD
Famotidine brand
Pepcid
Famotidine class
H2 antagonist
Famotidine MOA
Antagonizes H2 histamine receptors
Famotidine side effects
Dizziness, headache, taste changes, constipation, diarrhea
Famotidine dose
20-40 mg PO qD
Ibuprofen brand
Advil, Motrin
Ibuprofen class
NSAID
Ibuprofen MOA
Inhibits COX, reducing prostaglandin and thromboxane synthesis
Ibuprofen side effects
Dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity
Ibuprofen dose
300-800 mg TID or QID
Ibuprofen contraindications
ASA/NSAID induced asthma, 2nd/3rd trimester of pregnancy, CABG surgery
Ibuprofen BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, proliferation
Meloxicam brand
Mobic
Meloxicam class
NSAID
Meloxicam MOA
Inhibits COX, reducing prostaglandin and thromboxane synthesis
Meloxicam side effects
Dyspepsia, nausea, abdominal pain, dizziness, headache, rash, contipation, edema, GI bleed
Meloxicam dose
7.5-15 mg PO qD
Meloxicam contraindications
ASA/NSAID allergy, 2nd/3rd trimester of pregnancy
Meloxicam BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation
Naproxen brand
Naprosyn, Naprelan
Naproxen class
NSAID
Naproxen MOA
Inhibits COX, reducing prostaglandin and thromboxane synthesis
Naproxen side effects
Dyspepsia, nausea, abdominal pain, constipation, drowsiness, photosensitivity, GI bleed
Naproxen dose
IR/DR: 250-500 mg PO q12h, ER: 750-1000 mg PO qD
Naproxen contraindications
ASA/NSAID induced asthma, 2nd/3rd trimester of pregnancy, CABG surgery
Naproxen BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleeds, ulceration, and proliferation
Celecoxib brand
Celebrex
Celecoxib class
NSAID
Celecoxib MOA
Selectively inhibits COX-2, reducing prostaglandin synthesis
Celecoxib side effects
Headache, diarrhea, nausea, vomiting, peripheral edema, photosensitivity, GI bleed
Celecoxib dose
100-200 mg PO qD or BID
Celecoxib contraindications
Hypersensitivity to sulfonamides, 2nd/3rd trimester of pregnancy
Celecoxib BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, proliferation
Diclofenac brand
Voltaren, Cambia, Catafiam
Diclofenac class
NSAID
Diclofenac MOA
Inhibits COX, reducing prostaglandin and thromboxane synthesis
Diclofenac side effects
Dyspepsia, vomiting, headache, dizziness, rash, drowsiness, fluid retention, GI bleed
Diclofenac dose
DR: 50 mg PO BID or TID, ER: 100 mg PO qD
Diclofenac contraindications
ASA/NSAID allergy, 2nd/3rd trimester of pregnancy
Diclofenac BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation
Ketorolac brand
Toradol, Sprix
Ketorolac class
NSAID
Ketorolac MOA
Inhibits COX, reducing prostaglandin and thromboxane synthesis
Ketorolac side effects
GI bleed, perforation, ulcer, dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity
Ketorolac dose
10 mg PO q4-6h PRN
Ketorolac contraindications
Major surgery post-op, ASA/NSAID induced asthma, epidural or intrathecal use, CABG surgery
Ketorolac BBW
May increase risk of CV thrombotic events, may increase risk of fatal GI events such as GI bleed, ulceration, and proliferation; oral: up to 5 days treatment and only after parenteral use
Apixaban brand
Eliquis
Apixaban class
Factor Xa inhibitor, DOAC
Apixaban MOA
Factor Xa inhibitor, inhibiting blood coagulation
Apixaban side effects
Bleeding, anemia, nausea
Apixaban dose
5 mg PO BID
Apixaban contraindications
Pregnancy, active bleeding, unstable PE
Apixaban BBW
Increased risk when stopped too soon, risk of hematoma with epidural or spinal puncture
Dabigatran brand
Pradaxa
Dabigatran class
Anticoagulant, direct thrombin inhibitor
Dabigatran MOA
Directly inhibits thrombin
Dabigatran side effects
Dabigatran dose
150 mg PO BID
Dabigatran contraindications
Dabigatran BBW
Increased risk of thrombotic events with premature discontinuation
Heparin brand
Heparin
Heparin class
Anticoagulant
Heparin MOA
Activates antithrombin, which inhibits coagulation factors
Heparin side effects
Heparin dose
80 units/kg IV push followed by 18 units/kg/hr continuous infusion
Heparin contraindications
Severe thrombocytopenia, uncontrolled active bleeding, history of HIT
Heparin BBW
None
Warfarin brand
Coumadin, Jantoven
Warfarin class
Anticoagulant, vitamin K inhibitor
Warfarin MOA
Inhibits vitamin K dependent coagulation factor synthesis
Warfarin side effects
Bleeding, abdominal cramps/pain, nausea, vomiting, diarrhea, fatigue, headache, taste changes, edema
Warfarin dose
Individualized
