Cannabis

Cannabis definition

Drug derived from Cannabis plant containing THC

Primary psychoactive ingredient cannabis

THC

Non-psychoactive cannabis compound

CBD

Cannabis psychoactive varieties

Marijuana and hashish

Non-psychoactive cannabis uses

Medical CBD treatments

Cannabis inhalation pharmacokinetics

Rapid onset and shorter duration

Cannabis oral pharmacokinetics

Slower onset and longer duration

Why cannabis brownies used

THC dissolves in fat improving absorption

Why THC stays long in body

Stored in body fat

Cannabis pharmacodynamics receptors

CB1 receptors

Endocannabinoid source at synapse

Released from postsynaptic neuron

THC synapse mechanism

Retrograde signaling reduces neurotransmitter release

Why endocannabinoids are neuromodulators

Regulate release of other neurotransmitters rather than directly transmitting signals

Positive cannabis subjective effects

Relaxation and euphoria

Negative cannabis subjective effects

Anxiety and paranoia

Factors influencing cannabis experience

Dose, environment, expectations

Cannabis aggression effects

Does not increase aggression

Cannabis creativity effects

Evidence inconsistent

Cannabis memory effects

Impairs short-term memory

Cannabis attention effects

Reduces attention

Cannabis time perception effects

Slows perception of time

Cannabis IQ effects permanence

Usually not permanent

Cannabis categorization task effects

Impairs complex categorization performance

Cannabis physiological symptoms

Increased heart rate, red eyes, dry mouth

Cannabis medical glaucoma use

Reduces eye pressure

Cannabis medical appetite use

Stimulates appetite

Cannabis medical seizure use

Reduces seizures

Cannabis medical sleep use

Improves sleep onset

Cannabis antiemetic use

Reduces nausea

Cannabis antidepressant use evidence

Mixed and limited

Cannabis muscle spasm treatment

Reduces spasticity

Cannabis pain treatment

Provides pain relief

Best cannabis medical administration method

Not smoking; edibles, oils, or vapor preferred

Cannabis driving effects

Slows reaction time and impairs coordination

Cannabis motivation effects

Evidence inconsistent

Cannabis psychosis risk

Increased risk in vulnerable individuals

Cannabis hormone effects

Alters sex hormones

Cannabis immune effects

Possible immune suppression

Cannabis cancer risk

Evidence unclear

Cannabis dependence severity

Lower than nicotine and alcohol

Cannabis tolerance severity

Mild

Cannabis withdrawal symptoms

Irritability, sleep problems, reduced appetite

Cannabis treatment seeking prevalence

Much lower than nicotine and alcohol