Complemet proteins

C- Activation

Alteration of a complement protein

C inactivation

Denaturation of one of the early components in C activation pathway

C Fixation

Utilization of complement components by antigen- antibody complex

Hemolytic units

Dilution of serum sample

Convertase or esterase

Activated C component which act as proteolytic enzyme specific for subsequent components

Direct adaptive immune system to the site of infx

Lyse foreign cells

Opsonization

Tag invaders and cellular debris for clearance

Function of complement system

Inc vascular permeability

Recruit Monocytes and Neutrophils

Trigger secretion of immune response molecules

Complement system has proinflammatory effects which causes—,—,—

Inc susceptibility to infection

Autoimmune diseases

Deficiency in CP causes —,—

Complement protein

It is a heat labile protein and is easily inactivated at 56 C for 30 mins

Classical pathway

It is activated by Ag-Ab complexes

Properdin pathway

Alternative pathway was previously called —

Lectin pathway

It is a type of pathway that i ab independent

Antibodies: IgM, IgG3, IgG2, IgG1

Molecules: C reactive protein

Organisms: Viruses, mycoplasmas, protozoans, E. Coli

Classical pathway can be activated by what (enumerate mo n lahat nak)

Alternative pathway

This pathway is important as an early defense against pathogen

Alternative pathway

It can be amplification loop (works independently from formation of Ig)

Pillemer and associated in 1950

Named the term properdin

Bacterial cell wall with lipopolysaccharides

Yeast

Fungal cell wall

Virus

Virally infected cells

Tumor cell lines

Parasite (Trypanosomes)

Alternative pathway is activated by what

Mannan Binding lectin

Mannan binding lectin associated serine proteases 1 and 2

The lectin pathway is initiated by three proteins which are mainly

MBL, MASP1 and 2

Analogous to Ab C1qrs