immunology exam 2 🦠

Although phagocytic and bactericidal activity are normal, neutrophils are unable to reach the site of infection in which condition?

Lazy leukocyte syndrome

Congenital neutrophil abnormalities

Chadian-Higashi syndrome, chronic granulomatous disease, Lazy leukocytes syndrome, NOT myeloperoxidase deficiency

A hallmark feature of neutrophils of an individual with this condition is giant Ophelia granules. Individuals present with frequent skin infections, photosensitivity and hypopigmentation.

Chadiak-Higashi syndrome

In which condition is the patient unable to generate superoxide to produce an oxidative burst in their neutrophils?

Chronic granulomatous disease

A disorder in which peroxide activity is decrease but afflicted individuals are generally healthy.

Myeloperoxidase deficiency

Individuals with this rare genetic disorder that results in a deficiency of the enzyme that splits glucose from glucosylceramide. The cytoplasm of these cells has “wrinkled”” appearance.

Gaucher disease

This disease has multiple types: a sphingomyelinase deficiency in some types and the inability to properly catabolize cholesterol in another.

Neumann-Pick Disease

Which condition can be life threatening with most patients surviving into their 40’s but will be susceptible to infections from catalase positive bacteria?

Chronic Granulomatous disease

This condition exhibits impaired chemotaxis due to disruption of movement and transport of proteins within the neutrophil.

Chediak-Higashi syndrome

Shingling accumulates in phagocytes and impairs the function of the involved organs of patients inflicted with this disease

Niemann-Pick Disease

The causative agent in the disease syphilis is what organ?

Treponema-pallidum

Central nervous system involvement typically manifested during which stage of syphilis?

Tertiary syphilis

Which body fluid, with a positive VDRL test, is diagnostic for neurotrophic

Cerebrospinal fluid

Name the antibody in the RPR test?

Nonspecific reagin

Darkfield microscopy is used to diagnose the patient in which stage of syphilis?

Primary syphilis