MAO Inhibitors and Related Disorders

These flashcards cover the key concepts related to MAOIs, including mechanisms of action, side effects, dietary restrictions, and associated mental health conditions.

What is the mechanism of action for MAOIs such as Isocarboxazid and Phenelzine?

They inhibit monoamine oxidase, increasing levels of 5-HT and NE in the CNS.

Name one potential side effect of MAOIs.

Orthostatic hypotension.

What dietary consideration must patients on MAOIs keep in mind?

Avoid foods containing tyramine to prevent hypertensive crisis.

List one food high in tyramine that should be avoided by patients on MAOIs.

Aged cheeses.

What major concern is associated with bupropion?

The risk of seizures.

What condition can potentially arise from consuming tyramine while on MAOIs?

Hypertensive crisis.

Name one indication for the use of MAOIs.

Atypical depression.

What is the trade name for Selegiline?

Emsam.

How does the use of cold medicine relate to MAOIs?

Cold medications may contain ephedrine/amphetamines, which can provoke hypertensive crisis.

What effect do MAOIs have on anxiety symptoms?

They can contribute to increased anxiety, insomnia, agitation, and mania.

Which class of antidepressants has an increased risk for hypertensive crisis when taken with MAOIs?

TCAs (Tricyclic Antidepressants).

What should patients be advised to watch for as symptoms of a hypertensive crisis?

Headache, hypertension, tachycardia, vomiting, confusion, sweating.

What mental health conditions can MAOIs be used to treat?

Agoraphobia, OCD, and bulimia.

What is the trade name for Mirtazapine?

Remeron.

What are some common side effects associated with the use of MAOIs?

Anxiety, insomnia, agitation, and potential hypertensive crisis.