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Hormones
signaling molecules
- slow, long-lasting
- all locations
- affect the entire body, growth, development, digestion, reproduction, etc.
Neurons
nerve cells, transmit signal
- very fast
- specific locations
- immediate response, reflexes
signal transduction
hormone bind to receptor
Endocrine Signaling
hormones reach targets via bloodstream
- maintain homeostasis, stimuli, growth, development
Paracrine and Autocrine Signaling
Target cells lie near secreting cells - short distance diffusion
- Regulates blood pressure, nervous system function, reproduction
Autocrine - the target cell is secreting cell
Synaptic Signaling
synapses (part of neuron) secrete neurotransmitters to target cells - short distance diffusion
Neuroendocrine Signaling
neurosecretory cells secrete neurohormones into the bloodstream
3 types of hormones
Polypeptides (water-soluble) - cant diffuse across membrane, bind to surface receptor
amines (water-soluble) - cant diffuse across membrane, bind to surface receptor
steroids (lipid-soluble) - diffuse across membrane to cytosol
Pheromones
external hormone
- marking food trails
- defining territories
- warning of predators
- attracting potential mates
Hypothalamus
brain region controlling neuroendocrine signaling, hormone synthesizing
Pituitary gland
endocrine gland at the base of the brain
- Posterior pituitary
- Anterior pituitary
Posterior pituitary
extension of hypothalamus
- secretes hormones directly to bloodstream
- ADH (regulate water) and Oxytocin (milk)
Anterior pituitary
endocrine gland
- secret tropic hormones (tropins), release other hormones
Thyroid Regulation
hormone cascade pathway (trophic effects)
stimulus -> Hypothalamus -> TRH -> anterior pituitary -> TSH -> Thyroid glands -> T3 and T4 hormones -> Response
Tropisms
plant response toward/away from stimulus
Auxin
hormones, promote elongation in the tip
- Apical dominance (inhibit axillary buds), less bushy
de-etiolation
greening - response to light after a long period of insufficient light
Acid growth hypothesis
Auxin stimulates H+ pumps in membrane -> lower pH in cell wall -> expansins enzymes -> break cross-links (H-bonds) between microfibrils -> loosening the wall's fabric -> elongation
Plant hormones
abscisic acid (ABA), auxin, cytokinins, ethylene, gibberellins
abscisic acid (ABA)
Counter growth hormones
- close stomata, conserve water when drought
cytokinins
- stimulates axillary buds
- promote cell division, cytokinesis in root and shoot.
Gibberellins
cell division, stem elongation, fruit growth
seed germination (synthesis of hydrolytic enzymes to digest starch, proteins -> produce nutrients)
Ethylene
Mechanical stress
- Triple response
o stem elongation is slowed
o stem thickens
o stem grow horizontally
+ ein mutant (ethylene but no triple response)
+ ctr mutant (no ethylene but triple response)
leaf abscission, senescence (cell death)
- conserve nutrients
fruit ripening (positive feedback)
- "One bad apple spoils the bunch"
Photosynthesis
Light rxn + Calvin cycle
Light rxn (Light + H2O -> ATP, NADPH, O2)
in thylakoid membrane
- E from light excited e- (from H2O splitting, O2 released) PSII -> ETC -> PS1 -> NADP+ forming NADPH.
- e- moves down ETC released E to pump H+ to thylakoid space. ATP synthases move H+ down gradient, forming ATP.
Calvin Cycle (ATP, NADPH, CO2 -> sugar)
in the stroma
Carbon Fixation
- Rubisco adds 3 CO2 to organic molecule RuBP -> G3P (using ATP and NADPH)
Reduction & Sugar Formation
- Some G3P -> Glucose
- ATP, NADPH -> ADP, NADP+
- 6 CO2 form 1 Glucose.
Regeneration
Some G3P -> RuBP
Respiration
glucose -> 2 pyruvate -> acetyl CoA
Krebs Cycle
- NAD+ and FAD + e- and H+ -> NADH and FADH2
Oxidative Phosphorylation
- NADH and FADH2 'carry' H ions and e- to ETC
- O2 + H+ and e- -> H2O
- ETC passes e- down, release E gradually (no combust), pump H+ to intermembrane space
Chemiosmosis
- ATP synthases move H+ down gradient, forming ATP.
Autotroph (CO2 as carbon source)
Photoautotroph - light as E source (plants)
Chemoautotroph - chem as E source
Heterotroph (organic compounds as carbon source)
Photoheterotroph - light as E source
Chemoheterotroph - chem as E source (animals)
Role of O2
Obligate aerobes require O2
Obligate anaerobes poisoned by O2, live by fermentation, alternate e- acceptors (NO3, SO4)
Facultative anaerobes can use O2 or not
Prokaryote
bacteria and archaea, no nucleus
cell wall
maintain shape, protection
made of cellulose (plants) or chitin
bacterial have peptidoglycan -> target of antibiotics
Capsule
Covers the cell wall
adhere, defense
Plasmid
smaller ring of independent DNA
hypertonic environment
more "salt" outside -> cell shrinks
salt can be used to preserve foods
Gram-positive (purple)
simple structure
thick layer of peptidoglycan
less toxic.
Gram-negative (red)
complex structure
less layer of peptidoglycan, between 2 membranes
outer membrane contains lipopolysaccharides (carbohydrates bond to lipids)
Asexual reproduction
binary fission (Duplicate chromosomes -> 2 cells)
variation in prokaryotes
short generation times + large populations
metabolic functions of prokaryotes
infoldings of the plasma membrane
Endospores (thick coat, resistant cell)
bacterial dormancy - survive harsh conditions
Fimbriae
Short hair-like appendages - stick to surface
Pili (Sex pili) is longer, allow DNA exchange (Conjugation)
taxis
Move toward/away from a stimulus.
Flagella
dozens of different proteins form a motor (rings embedded in plasma membrane), hook, filament.
movement
Movement of prokaryotes
Running mode: counterclockwise rotation of flagella - move straight
Tumbling mode: clockwise rotation of flagella - change direction
Origins of Flagella
proteins added to an ancestral secretory system
Biofilms
Colonies of bacteria that adhere together to surfaces.
Metabolic cooperation
Nitrogen recycling
N-fixing: N2 -> NH4+
Nitrifying: NH4+ -> NO2- + NO3-
Denitrifying: NO3- -> N2
Microbes Mutualisms - plants and rhizobium bacteria
Plants supply sugar and shelter
rhizobium bacteria fix N2 for plants root.
Microbes Mutualisms - human
Healthcare
- Antibiotics, proteins (insulin), food supplements (probiotics)
Agricultural technology
- Clean oil spills, make transgenic plants
Industry
- Food production (yogurt, cheese), break down sewage, change to DNA
Waste -> fuel
essential
Water (dissolve, regulate temp)
minerals (bones, nervous activity)
protein (hormones, enzymes, tissues)
carb (energy)
fat (long-term energy)
vitamin (growth, facilitate nutrients)
ingestion
-suspension - filter food from water
substrate - live on and eat their food source
Fluid - suck nutrientrich fluid from hosts.
Deposit - sift to eat
Bulk - Large amounts food - most animals.
Intracellular digestion
lysosomes hydrolyze food inside food vacuoles
pinocytosis (liquid) and phagocytosis (food)
simple animal digestion
gastrovascular cavity (digestion + circulation)
complex animal digestion
alimentary canal (mouth + anus)
oral cavity digestion
teeth chew food
Salivary glands release saliva - contains amylase - break down starch, glycogen
pharynx -> esophagus -> stomach
Stomach digestion
chyme (food + gastric juice)
Gastric glands:
- Mucous cells - secrete mucus
- Chief cell - produce pepsinogen - inactive form of pepsin
- Parietal cells - secrete HCl
Small Intestine digestion
most enzymatic hydrolysis
Duodenum
- chyme + digestive juices from pancreas, liver, gallbladder, small intestine
- Pancreas produces
sodium bicarbonate - neutralizes acid
enzymes aid digestions
Small Intestine absorption
jejunum and ileum
- villi and microvilli increase absorption
amino acid and sugar carried away by blood
fat carried away by lymph
Fat absorption
Liver made Bile, stored in the gallbladder
- Bile salts digest fats
fat -> triglycerides by Bile salts
Lipase convert triglycerides -> fatty acids + monoglycerides -> diffuse into epithelial cells -> reform triglycerides -> Chylomicrons, carried away by lymph.
Large Intestine absorption
cecum - plant fermentation
colon - absorb water, house bacteria produce vitamin
rectum - store Feces
Dental Adaption
Carnivores
- Large, pointed incisor, canines - rip off preys
- Molar, premolar shred food
Herbivores
- Broad, ridged molar and premolar - grind plants
- Small, incisor and canines
Omnivores
- 6 molar crushing, 4 premolar for grinding
- 4 incisor for biting, 2 canines for tearing
Mutualistic Adaptations
Giant tubeworms - no digestive system - Rely on mutualistic bacteria
Rabbits and rodents pass food twice
Herbivores - can't digest cellulose -> fermentation chambers - mutualistic microorganisms digest cellulose
Herbivores fermentation chambers
Chewed food -> rumen and reticulum, mutualistic microorganisms digest cellulose
rechews cud from the reticulum -> further breaking down fibers
re-swallowed cud -> omasum, water removed
-> abomasum for digestion
obtains nutrients from the grass and mutualistic microorganisms.
Epithelial Tissue
Covers outside of the body
lines the organs
cavities within the body
points of exchange
Circulatory Systems
circulatory fluid
interconnecting vessels
heart
open circulatory system
Hemolymph bathes the organs directly.
No distinction between blood and interstitial fluid.
closed circulatory system
blood confined to vessels
distinct from the interstitial fluid
Fish gills
thin epithelium layer
gas exchange into blood capillary
countercurrent exchange system
-> Gas exchange over entire length -> effective
trachael system in insects
branching tubes throughout the body
short distance - no circulatory system - supply O2 directly to cell
Lungs
Air -> alveoli (air sacs), gas exchange occurs with blood capillaries
Lung diseases
Pulmonary edema - long diffusion distance
Emphysema - alveoli destruction
Fibrotic lung disease - thicken alveolar membrane
Breathing in birds
1 direction only
2 cycles of inhalation and exhalation required
pressure breathing
Positive - force air (gulp) to lungs - frogs
Negative - pull air (breath) to lungs
hemoglobin
iron-containing protein, carry 4 O2
Diving Mammals
high blood-to-body volume ratio
store O2 in their muscles - myoglobin proteins (more O2 affinity)
conserve O2 by
- Change buoyancy -> glide routing blood to vital tissues
- fermentation to produce ATP
Osmoconformers
iso-osmotic with surroundings, do not regulate osmolarity
Osmoregulators
control internal osmolarity
Salt water - dehydrating, salt gain
-> drink water and actively excrete salt
Freshwater - salt loss, water uptake
-> actively uptake salt, excrete water (urine)
Excretion
get rid of N waste
- NH3 (fish) - require water
- Urea (mammals)
- Uric acids (birds, insects)
Excretory process
Filtration: Filter body fluids -> filtrate
Reabsorption: Reclaiming valuable solutes
Secretion: Add wastes to the filtrate
Excretion: N wastes is released
Evolution of Excretory Systems
Protonephridium - flat worm - Excrete a dilute fluid
Metanephridia - earthworm - collect coelomic fluid, produce dilute urine
Malpighian Tubules - insects/arthropods - wastes as dry matter
Kidney - Vertebrates
Kidneys
CORTEX
- Proximal tubule - discrete toxins / reabsorb ions, water, nutrients/ maintain pH
- Distal tubule - selectively discrete toxins/absorb ions, water, nutrients/maintain pH
MEDULLA (OUTER + INNER)
- Descending Limp/Loop of Henle - reabsorb water
- Ascending Limp/loop of Henle: reabsorb NaCl
- Collecting duct - reabsorb water, NaCl
Circulatory system terms
ARTERIES (blood out) -> ARTERIOLES -> CAPILLARIES -> VENULES -> VEINS (blood return)
ATRIA - RECEIVE
VENTRICLE - PUMP
Single circulation
2 chambers - atria and ventricle
1 pump 1 circuits - in fish
Double circulation
2 pumps 2 circuits
Pulmonary/pulmocutaneous circuit - to lungs
Systemic circuit - to organs
amphibians circulation
3 chambers - 2 atrium, 1 ventricle
Incomplete ventricle: shut off blood flow to lungs when under water while continued blood flow to organs.
blood vessels
capillaries
- small, thin wall
- Blood flows through only 5-10% at any given time
Arteries
- medium-sized
- Aorta: biggest
Veins
- larger-sized due to smaller muscle and tissues.
- Have valves - prevent blood backflow
- vena cava: biggest (superior - lung, inferior - organs)
mammalian heart
4 chambers: 2 atria and 2 ventricles
Systole - heart contraction - pump
Diastole - heart relaxed - receive
The Cardiac Cycle - 1 Systole 1 Diastole
Atria, ventricle diastole
-> blood flow veins -> atria -> ventricle
Atria systole, ventricle diastole
-> blood flow atria -> ventricle
Atria diastole, ventricle systole
-> blood flow ventricle -> arteries
Sinoatrial (SA) node (pacemaker)
sets rate and timing at which cardiac muscle cells contract
can be controlled by hormones/nervous system to influence heart rate
Sphincter
ring muscle at the entrance to capillary beds
Open/close -> regulate blood flow to capillary
Blood composition
plasma - ions, proteins
cell - red blood, white blood, platelets
blood clotting
Clotting factors -> fibrin
Platelets - form sticky plug
platelets + blood + fibrin strands -> clot
Lymphatic system
immune system
returns fluid leaks (lymph) from capillary
- Blood pressure drive fluid out of capillaries
- Blood proteins pull fluid back (osmotic pressure)
Transport in Plants root
Apoplastic route - root hair passively uptake soil solution to Apoplast (cell wall)
Symplastic route - water, minerals that cross plasma membrane.
Transmembrane route - water, minerals transported from Apoplast -> protoplasts of cells of Epidermis & Cortex -> Symplast.
Endodermis
- Casparian strip, waxy, control entry to Stele. Only minerals in Symplast or minerals in endodermal cell can pass (no Apoplast)
Transport in the Xylem - cells in Stele discharge water, minerals -> Apoplast -> xylem -> shoot (bulk flow)
Stomata
Stomatal opening
Light triggers active transport of K+ into the vacuoles
Water moves into the vacuoles, following K+
The guard cells expand, stoma opens
Stomatal closing
No light, K+ pumping stops, K+ moves out
Water moves out of the vacuoles
The guard cells shrink, stoma closes
Xylem bulk transport (Cohesion-Tension Hypothesis)
Transpiration, Cohesion and Adhesion, root pressure
Transpiration
Evaporative cooling
negative pressure gradient, draws up water, minerals from roots
Allows gas/water exchange - photosynthesis
transpiration in mesophyll cells -> air-water interface more curved -> high surface tension -> negative pressure potential -> draw water from xylem
Cohesion, Adhesion
cohesion: water bonds water
adhesion: water bonds anything else
H-bond
Root pressure (weak)
Water and minerals absorption -> positive pressure