Conditions related to type III hypersensitivity & type IV hypersensitivity

What causes tissue damage in Type III hypersensitivity?

Small immune complexes are not efficiently cleared, leading to complement activation and localized inflammation.

Which autoimmune diseases are associated with Type III hypersensitivity?

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

What tissues are affected in Type III hypersensitivity-related autoimmune diseases?

Blood vessels (vasculitis in SLE) and joints (arthritis in RA).

What drives tissue damage in type IV hypersensitivity?

Antigen-specific T cells mediate delayed-type hypersensitivity, leading to tissue destruction.

Which autoimmune diseases are associated with type IV hypersensitivity?

Type 1 diabetes mellitus and celiac disease.

What is the target of T cells in type 1 diabetes mellitus?

Pancreatic β cells.

What triggers the T-cell response in celiac disease?

Uptake of gluten proteins in the digestive tract.