Anti-biotics, anti-ifectives, CKD meds (briefly)

Anti-infectives

Dr.Hawkins

Beta-lactams ______ bacterial ______ ______ ______. The _____-______ ring is responsible for antimicrobial action. They are and time-dependent killing so they are ______.

inhibit ; cell wall synthesis ; beta-lactam ; bactericidal

Penicillin VK (______)

Veetids ; 500mg PO q6h x10 days

Amoxicillin (______)

Amoxil® ; adults-500mg PO q8h x10 days (child: 1tsp PO q8h x10 day)

Amoxicillin-clavulanate (______)

Augmentin® ; IR- 500mg PO q8h (or 875mg BID)

Cephalosporins do NOT cover _______. Cetriaxone (_____) is CI in _________ _______.

Enterococci ; Rocephin ; Hyperbilirubinemic neonates

Cephalexin (_____)

Keflex ; 500mg PO q6h

Protein Synthesis Inhibitors:

Aminoglycosides, Tetracyclines, Macrolides, Clindamycin

Aminoglycosides ______ to the ______ ______ ______. They are therefore: ______. They have ______ ______ killing.

bind to the 30S ribosomal subunit ; bactericidal ; concentration dependent ; gentamycin, tobramycin, neomycin

Tetracylines are good for ______. Specifically doxycycline is good for ______ ______ ______ ______

Rickettsia ; Rocky Mountain Spotted Fever

Doxycycline (______). CI in ______

Vibramycin, Adoxa ; childhood ; 100 mg PO BID for 10 days

Macrolides _____ to _____ _____ _____ . Can cause _____ _____

Bind ; 50S ribosome subunit ; QT-prolongation

Arythromycin (______)

Zithromax ; Zpak- 2tabs on day 1, then 1 tab until all taken (pediatric :10mg/kg once day 1, 5 mg/kg daily X 5 days)

Metronidazole black box warning?

carcinogenic in mice and rats.

Metronidazole

Flagyl ; 500mg PO q8h

Sulfamethoxazole and Trimethoprim (______)

Bactrim ; 80/400 PO BID (mrsa- 2 tab PO BID)

Nitrofurantoin is ________ and CI in: _____, _____, ______ ______

bactericidal ; pregnant, <60crcl, liver disease

Nitrofurantoin (______).

Macrobid ; 100mg PO BID ; yes

Fluoroquinolones inhibits ______ ______ and ______ . The ending stem is -_______. Black box warnings include: ______ ______, ______ ______, ______ ______ in myasthenia gravis. Avoid with use of ______.

DNA gyrase and topoisomerase ; -floxacin ; peripheral neurotoxicity, tendon repture, CBS effects ; salt

IV anti-infectives

Dr. Guidry

Antibiotics?: ______, ______, ______ and ______

Penicillins, cephalosporins, AMGs, and misc (tetracyclines, macrolides, bactrim)

Penicillin G

Pfizerpen

Ampicillin/Sulbactam

Unasyn

Piperacillin/Tazobactam

Zosyn

Cefazolin

Ancef

Ceftriaxone

Rocephin®

Cefepime

Maxipime

Aminoglycosides have ______ ______ dosing and need to be ______ due to risk of ______, ______. In pregnant patients may cause ______ ______.

Daptomycin

Cubicin

Doxycycline

Vibramycin

Antifungals include: ______, ______, ______ __

Azoles, Echinocandins, Amphotericin B

Fluconazole

Diflucan

Voriconazole

Vfend

Isavuconazonium Sulfate

Cresemba

Micafungin

Mycamine

Caspofungin

Cancidas

Anidulafungin

Eraxis

IV Antivirals

Acyclovir, Ganciclovir, Foscarnet

Acyclovir

Zovirax

Ganciclovir

Cytovene

Foscarnet

Foscavir

CKD drugs

Dr. Guidry

Chronic kidney disease is defined as abnormalities in kidney structure/function for ________

≥3 months

CKD risk factors: _____, _____. AKI risk factors: ______, _____, ______ (BUN/SrCr)

DM, HTN ; Perfusion, structural, obstruction

Epoetin alfa (______, ______)
– Darbepoetin alfa (______)

Procrit®, Epogen® ; Aranesp®

Iron sucrose (______)

Venofer®

Iron dextran (______)

INFeD

Ferric carboxymaltose (______)

Injectafer®

Ferric gluconate (______)

Ferrlecit

Ergocalciferol (______)

Drisdol

Cinacalcet (______)

Sensipar

Calcium carbonate

Tums

Calcium acetate

PhosLo

Ferric citrate

Auryxia

Sucroferric oxyhydroxide

Velphoro

Sevelamer

Renvela

Lanthanum carbonate

Fosrenol

Sodium polystyrene sulfonate

Kayexalate

Patiromer

Veltassa

Sodium zirconium cyclosilicate

Lokelma

D5^1/2 NS w/ 20K @100: means what?

dextrose 5% in half normal saline with 20 mEqs of potassium at 100mL/hour

A1c goal: _____

Fasting FSBS: ___-____

Post prandial FSBS (1-2 hours): ______

>7.0%

80-130mg/dL

<180mg/dL

Metformin is the drug of choice for ____ ___. Start at _____ ____ then titrate up

DM2 ; 500mg qd

1. eGFR >60:

2. eGFR 45-60:

3. eGFR: 30-44

4. eGFR: <30

1. No dose adjustment

2. Monitor every 3-6 months

3. Max 500mg BID

4. CI

Metformin black box:

lactic acidosis