Drug Toxicity

Toxic effect of barbiturates

Coma

Toxic effects of Digitoxin

AV block

Toxic effect of heparin

Bleeding

Other terms for drug toxicity

ADR: adverse drug reaction

ADE: adverse drug event

ADE in 1937 causing the death of more than 100 people in the US

Elixir sulphanilamide

ADE in 1957 causing deformed children in West Germany

Thalidomide

ADE in 1967 causing SMON in more than 10,000 people in Japan

Clioquinol

ADE in 1990 showing liver damage

Pemoline and troglitazone

ADE in 2013 causing cardiotoxicity

Pioglitazone

On target binding MOT

Binds to the intended receptor with suboptimal kinetics, or in the wrong tissue, increasing the concentration

Effect of Diphenhydramine

Somnolence

MOT of Acetaminophen (Harmful metabolites)

Glutathione depletion in liver

Reactive intermediate of acetaminophen

N-acetyl-benzoquinonemine

Drug that causes Type I hypersensitivity

Penicillin

Symptoms of type II sensitivity

Hemolysis

Drug that causes type II sensitivity

Cefotetan

Target of type III sensitivity

IgG abd complement-binding soluble antigen

Drug that causes type III sensitivity

Mitomycin C

Symptom of type IV (delayed-type) sensitivity

Macular rashes

Drugs that cause type IV sensitivity

Sulfamethoxazole