Physiochemical Properties of Solutions - Hydrophilicity and Lipophilicity

Pharmaceutic

Hydrophilicity

Represents the affinity of a compound for an aqueous environment. The more hydrophilic a compound, the more water soluble it will be. Hydrophilic molecules are WATER LOVING.

Hydrophobic

The opposite of hydrophilic. Hydrophobic molecules are WATER FEARING.

Lipopphilicity

Represents the affinity of a compound for a lipophilic environment. It is commonly measured by its distribution in a biphasic system (e.g, PARTITION COEFFICIENT in octanol-water).

LogD

A measure of lipophilicity at a specific pH, with pH = 7.4 representing a common pH for consideration. It is commonly measured by its distribution in a biphasic system (e.g., DISTRIBUTION COEFFICIENT in octanol-pH buffered aqueous solution).

Polar Surface Area or TOpological Polar Surface Area

The sum of the contributions made by nitrogen and oxygen atoms and the polar hydrogens bonded to these heteroatoms to the molecular surface area.