AUSTIN- Part 1: Coagulation Pathophysiology

What is the primary function of hemostasis?

• A) To promote clot formation in healthy vessels

• B) To prevent blood loss by forming a plug in injured vessels

• C) To prevent clot formation in injured vessels

• D) To inhibit platelet aggregation at all times

B

Which of the following is a characteristic of arterial thrombosis?

• A) Platelet-rich clot formation

• B) Often associated with reduced blood flow

• C) Primarily involves fibrin and red blood cells

• D) Typically occurs in veins and venules

A

Which condition is most commonly associated with venous clots?

• A) Myocardial infarction

• B) Atherosclerosis

• C) Deep vein thrombosis

• D) Stroke

C

What is the primary component of venous clots?

• A) Platelets

• B) Fibrin and red blood cells

• C) Prothrombin

• D) Tissue factor

B

In which pathway does tissue factor (TF) play a crucial role?

• A) Extrinsic pathway

• B) Intrinsic pathway

• C) Common pathway

• D) All of the above

A

Which of the following substances limits clot formation?

• A) Thrombin

• B) Fibrinogen

• C) Antithrombin III

• D) Vitamin K

C

What is Virchow’s Triad?

• A) A series of treatments for clotting disorders

• B) A theory explaining the three factors predisposing to thromboembolic conditions

• C) A mechanism that reverses thrombus formation

• D) A cofactor in the coagulation cascade

B

Which of the following is a common cause of hypercoagulable states?

• A) Malignancy

• B) Hemophilia

• C) Vitamin K deficiency

• D) Thrombocytopenia

A

Which substance is primarily responsible for the recruitment and activation of platelets in the coagulation process?

• A) Vitamin K

• B) Thrombin

• C) Fibrinogen

• D) Antithrombin III

B

Which is the first step in the coagulation cascade?

• A) Activation of Factor X

• B) Conversion of prothrombin to thrombin

• C) Activation of tissue factor

• D) Platelet aggregation

C

Which of the following conditions is associated with bleeding disorders?

• A) Pulmonary embolism

• B) Deep vein thrombosis

• C) Vitamin K deficiency

• D) Myocardial infarction

C

What is the role of plasmin in fibrinolysis?

• A) Activates clotting factors

• B) Converts fibrinogen to fibrin

• C) Breaks down fibrin to dissolve clots

• D) Converts prothrombin to thrombin

C

Which condition is associated with arterial clots?

• A) Pulmonary embolism

• B) Deep vein thrombosis

• C) Stroke

• D) Myocardial infarction

D

What is a thrombus?

• A) A moving blood clot

• B) A solid mass of blood components that forms locally

• C) A substance that causes blood clotting

• D) A cell that prevents clotting

B

What is the primary role of von Willebrand factor (VWF) in platelet adhesion?

• A) It activates platelets

• B) It binds platelets to fibrinogen

• C) It binds platelets to subendothelial collagen

• D) It inhibits fibrin formation

C

Which of the following factors plays a key role in limiting clot formation?

• A) Thrombin

• B) Antithrombin III

• C) Platelets

• D) Fibrinogen

B

What condition is characterized by excessive bleeding due to impaired clotting?

• A) Deep vein thrombosis

• B) Hemophilia

• C) Pulmonary embolism

• D) Stroke

B

Which substance activates platelets by binding to GPIIb-IIIa receptors?

• A) Thromboxane A2

• B) Fibrinogen

• C) Prothrombin

• D) Antithrombin III

B

What is the main mechanism by which anticoagulants prevent clot formation?

• A) Inhibit platelet aggregation

• B) Inactivate clotting factors

• C) Increase fibrinolysis

• D) Promote thrombin formation

B

Which of the following is the most likely consequence of endothelial injury in the coagulation process?

• A) Platelet aggregation and clot formation

• B) Increased blood flow

• C) Inhibition of thrombin

• D) Vasodilation

A