3 Ideas of Cell theory:
All living things are made of 1+ cells
Cells are the simplest unit that can carry out life processes like growing or reproducing
Cells are created from other cells and cannot come from non-living matter
What is Scientific Theory?
An idea tested with proof and developed/verified by the scientific community
Types of cells
Prokaryotic Cells:
Do not contain a Nucleus or other membrane-bound organelles.
Types of Prokaryotes:
Bacteria
Archaebacteria
Eukaryotic Cells:
Contain Nucleus and other organelles each surrounded with a thin membrane.
Types of Eukaryotes:
Animals
Fungi
Plants
Protista
Have organelles.
Cell structures that perform a specific function for the cell.
Cells need organelles to perform activities such as:
Take materials from the environment
Store materials
Get rid of waste
Move substances to where they are needed
Reproduce
Similarities of both types of cells:
An outer membrane
DNA
Ribosomes
Duplicate to produce offspring
Cell Membrane:
Cell is surrounded by a double layered cell membrane
Function:
Control what enters and leaves the cell
To allow some substances to enter while keeping others out
Cytoplasm:
All organelles inside the cell are held in the Cytoplasm
Is made up of mostly water and some other substances
Function:
Temporarily stores material
Many chemical reaction take place in this organelle
Nucleus:
Contains the cell’s genetic information called chromosomes whihc are composed of DNA
The Nuclear Membrane separates the nucleus from the rest of the cell
Function:
It is the control center of the cell
Directs all the cell’s activites
DNA (deoxyribonucleic acid):
Contains all the genetic information in the nucleus
Carries coded instructions of all cell activity
When a cell divides, the DNA is copied so that each new cell has a complete set of DNA
Mitochondria:
“Powerhouse of the cell”
Cells contain multiple of this organelle
Multiple mitochondions are usually found in the muscle cell
Function:
The mitochondria is sometimes referred to as the powerhouse of the cell because they provide the cell with energy from glucose (sugar) through a process called cellular respiration
Word Equation: Glucose + Oxygen = Carbon Dioxide + Water + Energy
Endoplasmic Reticulum:
Three-dimensional network of branching tubes
It extends throughout the cytoplasm from the nuclear membrane to the cell membrane
2 types:
Smooth (SER) - No ribosome attached
Rough (RER) - Ribosomes attached
Function:
A transporting system; materials such as proteins can move from one location to the other inside the cell via the ER
Chemical reactions occur here as well
Ribosomes:
Found on the ER or free in the cytoplasm
Function:
Proteins are made on this organelle
Golgi Bodies (Golgi Apparatus):
Composed of many membraneous flattened “sacs”
Function:
Stores, modifies, and packages proteins
Transports proteins around and out of cells using vesicles
Plant Cells ONLY:
Cell Wall:
Outside of the cell membrane
Function:
Provides support and protection from physical injury
Chloroplast:
Contains green pigment called chlorophyll that gives plant leaves their green colour
Function:
Absorbs light energy which is used in photosynthesis
Word Equation for Photosynthesis: Carbon Dioxide + Water + Energy = Glucose + Oxygen
Vacuole:
Plants usually have 1 large vacuole which takes up most of the space inside the cell
Function:
Hold water and other materials
When full of water, turgor pressure keeps the cells swollen which keeps the plant’s stems and leaves firm
Interphase (90% of the cycle)
Interphase is the longest stage of the cell cycle
DNA replication and growth
Prepares for mitosis
Cells doing their everyday job
Prophase
Long strands of DNA condense into a compact called chromosomes
Chromosome: 2 sister chromatids held together by a centromere
Nuclear membrane breaks down
Centrides move to opposite poles
Metaphase
Chromosomes line up in the middle of the cell
Nuclear membrane dissolves completely
Anaphase
The centromere splits and sister chromatids separate
They are now called daughter chromosomes
They move to the opposite ends of the cell, pulled by spindle fibres
Telophase
Daughter chromosomes become thinner
New nuclear membrane forms around each group of daughter chromosomes
Cytokinesis
Cytoplasm divides
2 Identical daughter cells are formed
Animal Cell: Cell membrane pinches in at the equator, forming cleavage furrow.
Plant Cell: Cell plate forms where new cell wall is laid down
What is it?
Cancer is uncontrolled, unregulated growth of cells
Cells are going through the cell cycle too quickly
Reasons for cell division:
To grow
To repair and replace dead cells
Cancerous cells divide repeatedly out of control even when not needed
They crowd out normal cells and function abnormally
They can also destroy the correct functioning major organs
Tumours:
Benign - Mass of cells that don’t affect surrounding tissues
Malignant - Mass of cells that interfere with the function of neighbouring tissues
Causes of Cancer:
Mutation in DNA
Carcinogens - Smoking, exposure to sun, radiation, and toxic chemicals
Screening/Diagnosing Cancer:
Self Examinations: Breast, testicular, skin cancers
PAP test - Cervical Cancer
X-ray (mammogram) - Breast Cancer
Ultra sounds - To view heart and liver tumours
CAT and MRI
Endoscope - Colon Cancer
Biopsy - Surgical removal of tumour cells
Stem cell transplant
Immunology
Hierarchy: A system of organization in which people and groups are ranked one above the other according to status of authority
Tissue: A group of cells that have a similar structure and that function together as a unit and contain many types of cells.
Organ: A part of the body that performs a specific function
Organ system: A group of organs that work together to perform one or more functions
Cellular differentiation: The process during in which unspecialized young cells reach their mature specialized form and function.
Types of Tissues:
Epithelial:
Thin sheets of tightly packed cells
It is protection from dehydration
Low friction surfaces
Example: Lining of the digestive system
Connective:
Various types of cells and fibres held together by a liquid
It’s function is to support and be insulation
Examples: Bone, Tendons, Blood
Muscle:
Bundles of long cells called muscle fibres
Function - Movement
Examples: Heart, Muscles that make bones move and that surround the digestive tract
Nerve:
Long, thin cells with fine branches at the ends capable of conducting electrical impulses
Function - Sensory
Examples: Brain and nerves in the sensory organs
What are stem cells?
Stem cells are cells that are not yet specialized and that are in the process of differentiation. The body is made up of about 200 different kinds of specialized cells like muscle cells, nerve cells, fat cells, and skin cells.
Why are stem cells special?
Stem cells can self-renew to make more stem cells or differentiate into a specialized cell type
Pluripotent (Embryonic stem cells): Stem cells that can become many types of cells in the body
Get donated from embryos
Can be grown indefinitely in the lab at an unspecialized state
Can specialize into many different tissue types
Multipotent (Adult stem cells): Stem cells that can become only a few types of cells
Reside in most tissues of the body where they are involved in repair and replacement
Can only give rise to specific cell types
Induced Pluripotent Stem Cells (iPSC)
Get from adult cells in 2007 - recent discovery
Can be grown indefinitely in culture in an undifferentiated state
Similar properties to embryonic stem cells (pluripotent) and can differentiate into many tissue types
Can create stem cells directly from a patient for research
What makes stem cells so valuable?
Cell therapy → Cell-based therapy: Transplantation of specific cells and precursors
Research → Genetic, molecular, and biologic control of tissue growth and development
→ In understanding the function of genes and proteins
New drugs → Early efficacy and toxicity screening system for drug and chemical development
Organ system that takes in food, digests (break down) food, absorbs nutrients and excretes (get rid) of waste
Composed of digestive tract and accessory organs
Digestive tract – long tube with 2 openings
Ex. Earthworm
2 types:
Mechanical digestion
physical break down of food into small molecules through chewing
Chemical digestion
chemical break down of food into small molecules using enzymes (chemicals that speed up chemical reactions)
Mouth:
Starts the breakdown of the food
Mechanical digestion - Using teeth and tongue
Chemical digestion - Saliva
Saliva softens the food and teeth breaks the food into smaller pieces
Esophagus:
Muscular tube connecting mouth to stomach
Composed of smooth muscle tissues that pushes food down to stomach
Stomach:
Holds and mixes the food
Cells in the stomach lining produces enzymes and hydrochloric acid (HCl)
pH 2-3
Stomach is protected from HCl by mucus lining
Chemical digestion of food
Food mixture is called chyme
Small Intestine:
Chyme from stomach enters small intestines
Over 6-7 m long
Goblet cells produce mucus
Produces enzymes for chemical digestion
Food is completely broken down; nutrients are absorbed
Large Intestine:
1-2 m long
Absorbs water from indigestible food
Waste is excreted as semi-solid\
Liver:
Produces bile
fluid that breaks down fats
Detoxification
converts alcohol and drugs into soluble waste
Gallbladder:
Pouch located underneath the liver which stores bile
Pancreas:
Located underneath the stomach
Produces enzymes for chemical digestion
Produces insulin (hormone) that regulates the sugar level in blood
Digestive system disorder:
Ulcers
Stomach lining breaks down and stomach cells are exposed to HCl
Could lead to cuts and holes in stomach
Causes: bacteria, diet, stress
Treatment: antibiotics
Functions:
Transports substances around the body
Transports white blood cells to infected body parts
Regulates body temperature
The Circulatory System consists of Blood, Blood Vessels, and Heart
Components of Blood:
Erythrocytes (red blood cells)
45% of blood volume
Flattened disk shape
Does not have a nucleus
Contain a protein called hemoglobin – transport oxygen to cell
Leukocytes (white blood cells)
Less than 1% of blood volume
Many different types
Contain nucleus
Fight off infections
Platelets
Less than 1% of blood volume
Tiny cells that help in blood clotting
Plasma
Liquid part of blood
55% of blood volume
Contains proteins, vitamins, minerals, ions
Blood is made from stem cells bone morrow
Main types of blood vessels: Arteries, Veins, Capillaires
Arteries
Arteries take blood __A__WAY from the heart
Must withstand high blood pressure, therefore walls are very thick
Veins
Veins bring blood BACK to the heart
Lower blood pressure therefore walls are not as thick as arteries
Capillaries
Walls are very thin
Oxygen and nutrients diffuse from blood into body cells
Carbon dioxide and wastes diffuse from body cells into blood
The entire body is covered with a network of capillaries
The Heart:
4-chambered pump that moves blood around the body
Composed of :
Cardiac muscle tissue
Nerve tissue
Connective tissue
Epithelial tissue
Blood flows from top chambers (atria) to bottom chambers (ventricles) and right side to left side
When cardiac muscle contract the heart beats
Heart beat changes. When?
Physical activity
Temperature
Stress
Drugs
Circulatory system diseases:
Coronary artery disease
Coronary arteries carry blood that provides oxygen and nutrient to the heart
These blood vessels can be blocked with fat, blood clots and reduce blood flow to heart
Can lead to heart attack
Causes:
Tiredness
Dizziness
Chest pain
Shortness of breath
Nausea
Symptoms:
Tiredness
Dizziness
Chest pain
Shortness of breath
Nausea
Diagnosis:
Angiogram – X-ray image of heart
Electrocardiogram (ECG)
Treatments:
Drugs
Bypass surgery
Functions:
Provides the cells with O2 and removes CO2 from cells
Works with the circulatory system to move O2 and CO2
Nasal passage:
Passageway is lined with hairs and mucus
Act as a filtering system; cleans the air
Warms the air
Pharynx:
Back of the mouth-throat
Leads to esophagus or trachea
Epiglottis:
Flap covering the trachea
Prevents food from entering trachea
Larynx:
Vocal cords
Produces sound
Trachea (windpipe):
Moves air down to lungs
Supported by cartilage rings
Lined with ciliated (microscopic hair), epithelial cells
Cilia sweep particles out - coughing
Bronchi and bronchioles:
Trachea leads to bronchus (pl. bronchi), which further divides into smaller bronchioles
Supported by cartilage rings
Moves air along respiratory pathway
Alveoli:
Bronchioles eventually branch into alveoli
Thin-walled, tiny air sacs
Covered with blood capillaries
The alveoli provides a huge surface area in the lungs for gas exchange
Gas exchange:
O2 diffuse from alveoli into capillaries
CO2 diffuse from capillaries into alveoli
Lungs:
Houses the bronchi, bronchioles and alveoli
Right lung has 3 lobes
Left lung has 2 lobes (to accommodate the heart)
Diaphragm
Dome-shaped sheet of muscle, underneath the lungs
Contracts and relaxes to change the volume of the lungs when breathing
Breathing:
Movement of air into and out of the lungs
Inhalation – movement of air into the lungs
Diaphragm flattens and intercostal muscles contract
lung volume increases; the pressure decreases
air moves into the lungs
Exhalation – movement of air out of the lungs
Involves the diaphragm and intercostal muscles (ribcage)
diaphragm is dome-shaped and intercostal muscles relax
lung volume decreases; the pressure increases
air moves out of the lungs
Control of Breathing:
Breathing is involuntary
Controlled by a part of the brain that detects [CO2]
↑ [CO2], brain sends an impulse to the diaphragm, intercostal muscles and heart to ↑ breathing and heart rate