Drugs Affecting Coagulation

Thrombosis

Inappropriate clotting; Medical conditions involving formation of thrombi reducing blood flow or causing total occlusion of a vessel

Bleeding

Inability to clot; medical condition characterized by excessive bleeding (less common)

Drugs used to affect blood coagulation and resolution

Antiplatelet Agents

Anticoagulants

Thrombolytic Agents

Anticoagulant Adjunctive therapy

Hemorrheologic Agent

Drugs used to control bleeding

Antihemophilic agents

Hemostatic agents

Antiplatelet Agent drugs

Aspirin

Clopidogrel/Plavix

Ticagrelor/Brilinta

Aspirin

A Antiplatelet drug used for decreation of platelet formation in low doses and for mild/moderate pain

Low dose = reduced platelet aggregation and blood clot formation

High dose= inhibition or prostacyclin

Clopidogrel/ Plavix

An Antiplatelet drug used to decrease formation of platelet aka blood thinner to prevent dangerous blood clots

Ticagrelor/Brilinta

An Antiplatelet drug that is used to prevent blood clots to reduce the risk of heart attack, stoke, and heart-related death in high risk patients

Anticoagulant Drugs

• Heparin

• Warfarin

• Antithrombin III/ Thrombate III

• Argatroban

• Enoxaparin

• Dabigatran/Pradaxa

• Rivaroxaban/Xarelto

• Apixaban/Eliquis

Heparin

An anticoagulant drug that has and immediate onset that interferes with normal coagulation by blocking the clotting cascade and thrombin formation

Warfarin

An anticoagulant drug that has an onset of 3 days and lasts 4-5 days that also interfere with normal coagulation by blocking the clotting cascade and thrombin formation; also requires frequent blood tests

PTT

Activity of intrinsic pathway coagulation; used to adjust doses for heparin

INR

Standardized measure of prothrombin levels; used for warfarin dose adjustment

Antidote Heparin Overdose

Protamine Sulfate

Prothrombin complex concentrate Kcentra

Warfarin Antidote related to bleeding

Vitamin K

Warfarin antidote for anticoagulant induced prothrombin deficiency (High INR)

Thrombolytic Drugs

• Alteplase/Activase (TPA)

• Reteplase/retavase

• Tenecteplase/TNKase

• Urokinase/Abbokinase IV declot

Alteplase/Activase

A Thrombolytic drug that breaks down the thrombus that has been formed by stimulating the plasmid systems. Used for Acute MI, Acute ischemic Stroke, and acute PE