PHAR 9968 Dermatology

Which of the following are considered primary functions of the integumentary system? SELECT ALL THAT APPLY

A. Physical barrier

B. Thermoregulation

C. Vitamin C synthesis

D. Excretion of waste

A,B,D

Which of the following skin lesions appears flat and can only be differentiated by surrounding skin color?

A. Papule

B. Macule

C. Nodule

D. Plaque

B

What is a main factor that causes acne vulgaris?

A. Enhanced sebum production

B. Decreased filaggrin production

C. Increased levels of IgE

D. Abnormal activation of the immune system mediated primarily by dendritic cells the IL-12, IL-17, and IL-23

A

Which of the following topical prescription agents is indicated for both acne vulgaris and psoriasis?

A. Anthralin

B. Clascoterone

C. Erythromycin

D. Tazarotene

D

Which of the following hormonal agents carries a risk of worsening acne due to increased androgenic effects?

A. Ethinyl estradiol

B. Spironolactone

C. Norethindrone

D. Clascosterone

C

Which class of medications are indicated for treating moderate to severe psoriasis? SELECT ALL THAT APPLY

A. TNF-α inhibitors

B. IL-13 inhibitors

C. Tetracyclines

D. PDE4 inhibitor

A,D

Dermatological colonization of which microorganism increases the risk of developing atopic dermatitis?

A. Staphylococcus epidermidis

B. Staphylococcus lugdunensis

C. Staphylococcus aureus

D. Staphyloccocus muciniphila

C

Mutations in which gene increases the risk of developing atopic dermatitis?

A. PSORS1

B. HLA-B

C. FLG

D. SLC2A9

C

Which of the following classes of medications are indicated for atopic dermatitis? SELECT ALL THAT APPLY

A. Retinoic acid receptor inhibitors

B. Keratolytics

C. IL-13 inhibitors

D. JAK inhibitors

C,D

Which of the following is an inherit risk of all biologics used to target interleukins? SELECT ALL THAT APPLY

A. Increased risk of infection

B. Hepatotoxicity

C. Anaphylaxis

D. Development of neutralizing antibodies

A,B,D

Presence of the which of the following HLA-B alleles increases the risk of causing dermatologic reactions to allopurinol?

A. HLA-B*15:02

B. HLA-B*58:01

C. HLA-B*57:01

D. HLA-B*13:01

B

Which of the following allergic cutaneous drug eruptions present with a fever? SELECT ALL THAT APPLY

A. Drug rash with eosinophilia and systemic symptoms (DRESS)

B. Bullous drug eruption

C. Acute generalized exanthematous pustulosis (AGEP)

D. Urticaria

A,C

Which of the following drugs is known to cause hyperpigmentation (AKA ceruloderma)?

A. Digoxin

B. Sildenafil

C. Amiodarone

D. Prednisone

C

Which of the following drugs carries a black box warning of causing serious dermatologic disorders such as steven-johnson syndrome (SJS) or toxic epidermal necrolysis (TEN)? SELECT ALL THAT APPLY

A. Carbamazepine

B. Lamotrigine

C. Drospirenone

D. Codeine

A,B

Which of the following treatments should be initiated if a patient presents with a severe dermatologic drug reaction? SELECT ALL THAT APPLY

A. Discontinue offending agent and avoid cross-sensitizers

B. Provide supportive care to maintain BP and electrolytes

C. Initiate prophylactic antibiotic therapy

D. Use a short course of corticosteroids

A,B,D