2020 test 3 memory

Antineopiastic drugs use

Treat malignancies, disease w/ inflammation

Plastic MOA

Cancer chemotherapeutic agent

Suppresses growth of cells and attempts to destroy and prevent spread of malignant cells

G1

Postmitotic / pre DNA synthesis (cell just divided and is building stuff to grow)

G1 = growth 1

S phase

DNA synthesis (copies DNA from 1 → 2 sets)

S= DNA synthesis

G2

Premitotic / post DNA synthesis (final checks before getting ready to split)

G2= Get ready 2 split

M phase

Mitosis (cell splits into 2)

M= make 2

De novo resistance

Always resistant

De novo = from new

Acquired resistance

Occurs through natural selection of mutations

Specific plastics

Anti metabolites, plant alkaloids, hormones, tamoxifen, hydroxyurea, procarbazine

Plant people who love water and hate taxes are pro antimeta

Antimetabolites

Attack during phase by interfering w/ purine and pyrimadine

Ppl are anti meta bc there's S and P on there

Plant alkaloids

Mitotic inhibitor, arrest cells in metaphase/mitosis

Monster plants paralyze you from splitting

Hormones

Interrupt G phase, ex prednisone

Women W/ hormones wear G strings

Tamoxifen

Antiestrogen, manage/prevent breast cancer

Tami was breast cancer so she's anti estrogen

Hydroxyurea

Interferes w/ RNA synthesis

H2O doesn't like RNA

Procarbazine

Chromosomal break

Mac book pros are better than chrome bc they don't break

Non specific plastics

Antibiotics, steroids, cisplatin, alkylating agents, estrogen

Cis ppl take steroid estrogens and antibiotics to become Kyla

Antibiotics

Solid tumors

Ppl who are anti bi have said beliefs

Steroids

Suppress lymphocytes in leukemia and lymphoma

Losers take steroids to suppress their Loserness

Cisplatin

Heavy metal complex of platinum

Platin= platinum heavy metals

Alkylating agents

Contain radicals that react w/ in all cycles

Kyla is a radical who destroys every phase

Estrogens

Treats pain in inoperative breast cancer

Estrogens gave my mom pain but it helps ppl W/ breast cancer

Bone marrow suppression

-penia, anemia, -cytosis, immune, bone

Dermatologic

SJ, erythema, exfoliative dermatitis, alopecia

SJ, erythema, sheds your skin and hair

Oral

Xerostomia, impaired taste, tooth/gum sensitivity and bleeding, mucous infection (stomatitis), ulcers

Eating dry plastic tastes weird and can make your gums/teeth sensitive and bleed, it also can spread infection and ulcers that make your tongue swell

Toxicity

Liver, brain (neuro), kidney, germ cells

GI

Nausea, bloody poo

Osteonecrosis

Biphosphinates

DH implications

Optimize OH before chemo

Procedures align w/ highest level of formed blood elements (right before chemo bc have most WBC to prevent infection/bleeding)

Pancreatic hormones

Primary secreted by langerhans - insulin and glucose

Other - peptides

Insulin vs glucagon

Insulin- released when ↑ glucose, puts glucose into cells/out of blood, stores fat

Glucose- released when ↓ glucose, release glucose into blood

Type 1 diabetes

Autoimmune destruction of pancreatic beta cells = complete lack of insulin secretion= ↑ glucose in blood, ↑ glucagon secretion, ketosis

Type 2 diabetes

Secretes enough insulin to prevent ketosis but not normalize plasma glucose, insulin resistance develops, 90-95% of pts

Oral w/ diabetes

Xerostomia- dry, cracked, perio

Infection- ulcers, glossitis

Diabetes cautions/contras

Epic, opioids, analgesics, GA, glucocorticosteroids

Diabetes complications

Heart, brain, eye, healing

Diabetes measurements

Plasma glucose, glycosylated hemoglobin

A1C levels

6.4-8 = good

8-9 = ok

9 + = bad

Sulfonylureas

Stimulate release of insulin from pancreas B cells, ↑ insulin sensitivity

Sulfon squeezes out insulin but too much can cause hypoglycemia and weight gain bc insulin stores fat

Biguanides

Metformin (glucophage), ↑ insulin sensitivity in kidney and peripheral

Metformin makes your kidney and P big time sensitive

Meglitnides

-glinide, stimulate release of insulin after meals

Mega glide of insulin release after meals but can cause hypoglycemia

Thiazolidinediones

-litazone, ↑ insulin sensitivity in adipose tissue, skeletal muscle, liver

Actor Ava gets in the zone by becoming sensitive but her cells hold her tears and glucose causing weight gain

Dipeptidyl-peptidase-4 (DDP-4) inhibitor

Inhibit DPP-4 enzyme (inactivates glp-1 and glucose)

Juan gliptin is a dih who hates sugar and gIp-1’s

A-glucosidase inhibitor

Slower carb breakdown= slower digestion= slower glucose rise

A= after carb-ose digestion slows but it can cause gas+diahrrea

Glucagon like peptide-1 receptor agonist (GLP 1)

-tide, ↓ digestion/appetite, nausea/vomit, diarrhea, pancreatitis, hypoglycemia w/ sulfonylurea

Vic and byetta use GLP-1's but they excrete from both ends w/ inflamed pancreases, they stoop low as sulfur

GLP-1

Incretin hormone, ↑ insulin/ ↓ glucagon = slow stomach

Sodium glucose transporter-2 inhibitors

Block reabsorpton of glucose in kidneys → excess G excreted

Extra sodium and sugar floz invoking pee which causes private infections, ↑ urination, ↓ poop, nausea

Pramlintide

Modifies gastric emptying preventing post food rise and hunger

Pauses GI emptying post eating pausing hunger which makes you nauseous -headache vomit

Bile acid sequestrants

↓ LDL cholesterol, ↑ glp-1, interfere w/ absorption of oral drugs (liver makes bile from cholesterol, this binds to bile causing it to excrete so the body makes more using cholesterol)

Cole Chol is a bile man w/ a low ding a ling LDL, his heart burns his poop comes out his mouth not bum, he's hooked on GLP 1s so he can't have other oral drugs

Uncocious hypoglycemia

IV dextrose 50%