Adrenergic Antagonists

What’s the MOA of phenoxybenzamine

Non-competitive alpha-1 & alpha-2 antagonist

What’s the primary indication of phentolamine

Hypertension in pheochromocytoma

What’s the primary indication of phenoxybenzamine

Hypertension in pheochromocytoma

What’s the MOA of phentolamine

Competitive alpha-1 & alpha-2 antagonist

What side effect does phentolamine cause

Reflex tachycardia due to blockade of pre-synaptic alpha-2 receptors

What’s the MOA of doxazosin

Alpha-1 antagonist

What’s the primary indication of doxazosin

Treats BPH (benign prostate hypertrophy) by relaxation of bladder & prostatic smooth muscle

What’s the MOA of atenolol

Beta-1 blocker

What’s the primary indication of atenolol

Hypertension, angina, acute myocardial infarction

What’s the MOA of metoprolol

Hypertension, angina, acute myocardial infarction

What’s the MOA of carvedilol

Non-selective beta-1, beta-2, alpha-1 antagonist

1. B1 blockade —> ↓ HR, ↓ contractility, ↓ cardiac output

2. B2 blockade —> mild bronchoconstriction & ↓ glycogenolysis

3. A1 blockade —> vasodilation —> ↓ peripheral vascular resistance

What’s the primary indication of carvedilol

Hypertension & heart failure

What’s the MOA of labetalol

Beta-1, beta-2, alpha-1 antagonist

1. b1 blockade —> ↓ HR, ↓ contractility

2. b2 blockade —> possible bronchoconstriction

3. a1 blockade —> vasodilation —> ↓ peripheral resistance

What’s the primary indication of labetalol

Hypertension