immunosuppressants

main indication for immunosuppressants

main indication for immunosuppressants

preventing organ rejection for transplants

calcineurin inhibits ___

interleukin-2

calcineurin inhibitors are also used for

psoriasis and RA

prototype calcineurin inhibitor

cyclosporine

three main adverse effects of cyclosporine

nephrotoxicity

infection

HTN

avoid taking cyclosporine during __

pregnancy

cyclosporine is increased by

-azoles, erythromycin, ampho b

cyclosporine is decreased by

phenytoin, rifampin, bactrim, nephrotoxic drugs

cyclosporine interacts with

grapefruit juice

alternative to cyclosporine

tacrolimus

it is recommended to take __ with tacrolimus

glucocorticoids

two toxicities caused by tacrolimus

nephro and neuro

tacrolimus is inhibited by what three things

erythromycin, fluconazole, grapefruit juice

tacrolimus is induced by

rifampin

prototype MTor inhibitor

sirolimus

sirolimus is best for __ transplant rejection

renal

sirolimus raises what two levels

cholesterol and triglyceride

sirolimus interacts with what two foods

high fat and grapefruit juice

cytotoxic drugs kill all ___ cells

proliferating

prototype cytotoxic drug

azathioprine

azathioprine main adverse effect

bone marrow suppression

azathioprine is a ___ drug

teratogenic