Cell mediated response

Describe third line defence

Specific defences; adaptive

Name 3 specific defences

* lymphocytes
* antibodies
* memory cells

What is a lymphocyte

type of white blood celll

is a lymphocyte bigger or smaller than a phagocyte

smaller

where and when are lymphocytes produced

in bone marrow before birth

are lymphocytes involved in phagocytosis

no

Where do T cells MATURE?

thymus gland

where do B cells MATURE?

bone marrow

What are the stages of cell mediated response?

1. Antigen presentation
2. Clonal selection
3. Clonal expansion
4. T Killer Cell activation
5. Down regulation

Explain the steps of cell mediated response?

1. APC release cytokines
2. Cytokines activate T helper cells
3. T helper cells complementary to antigen on APC
4. T helper cells divide mitosis and release more cytokines
5. These cytokines activate T killer cells
6. T killer cells release perforins to punch holes into cell surface and allow toxins to enter infected cells
7. T helper cells can differentiate into T memory cells- can turn into T killer cells if pathogen reenters
8. T regulator cells prevent T killer cells from killing unaffected host cells and shut down immune response once body is clear