MIC102

ETEC disease

gastroenteritis

ETEC toxin

S.T. and L.T.

ETEC flagella

yes

ETEC pili

yes

ETEC T3S

no

S.T.

stable toxin, single polypeptide, targets guanylate cyclase

L.T.

liable toxin, 1 A subunit and 5 B subunits

L.T. A subunit

toxic activity

L.T. B subunit

binds to the target cell and delivers A

EPEC disease

gastroenteritis

EPEC flagella

yes

EPEC pili

yes

EPEC T3S

yes A/E lesion

EPEC toxin

none

EHEC disease

dysentery

EHEC flagella

yes

EHEC pili

yes

EHEC T3S

A/E lesion

EHEC toxin

shiga toxin → ribosomes

EIEC disease

gastroenteritis

EIEC flagella

yes

EIEC pili

yes

EIEC T3S

yes invasion

EIEC toxin

none

salmonella enterica

flagella

yes

salmonella enterica

pili

yes

salmonella enterica

T3S

T3S-1 → invasion

T3S-2 → survival in phagocytosis

salmonella enterica

toxin

none

salmonella enterica disease

gastroenteritis

salmonella typhi

flagella

no

salmonella typhi

pili

yes

salmonella typhi

T3S

T3S-1 → invasion

T3S-2 → survival in phagocytosis

vi antigen — capsule made of polysaccharide

salmonella typhi

toxin

none

salmonella typhi

disease

typhoid fever

shigella dysentery

disease

dysentery

shigella dysentery

flagella

no

shigella dysentery

pili

yes

shigella dysentery

T3S

yes invasion

shigella dysentery

toxin

shiga and IcsA — actin based motility

yersinia enterocolitica disease

gastroenteritis

yersinia enterocolitica

flagella

yes

yersinia enterocolitica

pili

yes

yersinia enterocolitica

T3S

yes block phagocytes

yersinia enterocolitica

toxin

none

yersinia enterocolitica invasin

yersinia pestis flagella

no

yersinia pestis

pili

yes

yersinia pestis T3S

yes block phagocyte activities

yersinia pestis toxin

none

yersinia pestis disease

bubonic plague and pneumonic plague

pla

blocks feeding by fleas