GTPase's

GTPase

small, catalytic proteins that have the ability to bind guanine nucleotides

GTPase when bound to GTP is what (inactive or active)

active conformation

GTPase when bound to GDP is what (inactive or active)

inactive conformation

bound GTP is naturally hydrolyzed into what

GDP

GEFs

• guanine nucleotide exchange factors

• precisely controls GTPase activation

• stimulate the exchange of GDP for GTP

  • pushes GTPases into their active conformation

GAPs

• GTPase activating proteins

• stimulate the rapid hydrolysis of GTP to GDP

  • pushes GTPases into their inactivate conformation

GDIs

• guanosine dissociation inhibitors

• bind to GTPases and prevent the release of GDP

  • maintain GTPases in their inactive conformation

GTPase switch diagram/picture