Dementia

What percent of information can cognitively healthy individuals retain?

80%

What percent of the brains weight is reduced as a person ages?

15%

Who shows less decline in cognitive abilities with age?

Women

When do brain cells begin to die?

Mid 30’s

The #1 cause of dementia

Alzheimer’s

The #1 risk of Alzheimer’s

Getting older

The hallmark of Alzheimer’s

Inability to form new memories

What two neural mechanisms impact Alzheimer’s?

Neuronal plaques and neuro-fibrillary tangles

What area of the brain is impacted by neuronal plaques?

Hippocampus

What happens with acetylcholine in Alzheimer’s?

There is less of it produced

What protein is found at the core of neuronal plaques?

Beta-Amyloid Protein

What protein is found within neuro-fibrillary tangles?

Tau-Protein

What chromosomal disorder has a much higher rate of Alzheimer’s?

Down’s Syndrome

What did the nun study find?

#1 predictor of not having dementia early is writing samples from 1^st grade

What is the best way to prevent dementia symptoms?

Physical exercise

Alzheimer’s drugs that are designed to destroy amyloid

Adulhelm and Leqembi

Class of drugs that help Alzheimer’s symptoms by breaking down acetylcholine

Acetylcholineesterase

Type of dementia where the neurons can’t get oxygen from blood vessels and die

Vascular Dementia

Type of dementia caused by prolonged alcohol abuse

Korsakoff’s dementia

What chromosome is linked with the amyloid precursor protein?

Chromosome 21

What causes Korsakoff’s dementia?

Thymine deficiency (B1 deficiency)

A life threatening event caused by extreme B1 deficiency

Wernicke’s-Korsakoff’s Event