Leptin

adipose tissues

fatty tissues composed of fat cells specialized in synthesis/storage of fat globules

what secretes/produces leptin?

adipose tissue cells (adipocytes)

blood leptin concentration control facors

food intake, amount of adipose tissues in body

where are leptin receptors found?

in brain’s hypothalamus

the relationship between apetite and leptin is

inverse

what will happen to leptin levels if you lose wieght?

they will fall

why does leptin regulate energy intake and fat stores?

so that weight is maintained within a narrow range

if apetitie levels decrease

energy expenditure will increase

is there a gene for obesity?

yes the ob (obese) allele

mice cannot produce leptin if

they have two homozygous recessive ob alleles; they have no apetite inhibition

how did leptin jections affect mice?

their body mass reduced by 30%

unlike mice, obese people have

high leptin levels in their blood; mice experiment did not have same results in humans

what is wrong with the receptor cells in humans with the obesity allele?

the receptor cells in the hypothalamus are no longer responsive to leptin; no apetite inhibition

when leptin increases apetite

temperature decreases

the metaboolix rate is directly related to

body temperature

the body only uses lipids for energy when

ATP is needed and there aren’t enough carbohydrates

weight loss refers to

adipose tissue density

leptin is essential for

balancing the normal body weight