Genetics_Ch12_Fall_2024

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What are the three proposed models of DNA replication?

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1

What are the three proposed models of DNA replication?

Conservative replication, Dispersive replication, Semiconservative replication.

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2

Who conducted the landmark DNA replication experiment in 1958 using isotopes of nitrogen?

Meselson and Stahl.

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3

What is the expected banding pattern of DNA after one round of semiconservative replication?

DNA appears as two bands: one light (14N) and one intermediate.

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4

What are the products of bacterial theta replication?

Two circular DNA molecules.

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5

In what direction does DNA synthesis proceed during replication?

From 5′ to 3′.

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6

What is the role of DNA ligase in DNA replication?

DNA ligase connects nicks between Okazaki fragments once RNA primers are removed.

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7

What does the term 'redundant origins of replication' refer to in eukaryotic cells?

Each chromosome contains numerous origins of replication.

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8

What problem does telomerase address during linear DNA replication?

It prevents chromosomes from shortening during cell division.

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9

Which eukaryotic DNA polymerase is primarily responsible for lagging-strand synthesis?

DNA polymerase δ (delta).

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10

What occurs during homologous recombination at a Holliday junction?

Branch migration and strand exchange between homologous DNA molecules.

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