Protein Processing in the Endoplasmic Reticulum

Protein Processing

Folding

Disulfide bond formation

Glycosylation

Folding diagram

ER chaperone types

BiP

Calreticulin

Calnexin

Disulfide Bond Formation diagram

Glycosylation diagram

Glycosylation and Folding process diagram

what facilitates chaperone binding

Calreticulin

Calnexin

what removes glucose

Glucosidase

proteins fold into

three-dimensional shapes with the assistance of molecular chaperones that promote proper folding of proteins.

Disulfide bonds

between cysteines are formed in the oxidizing environment with the help of protein disulfide isomerase.

Proteins are glycosylated by

addition of an N-linked carbohydrate group.

glucose

A single glucose unit on the end of an N-linked carbohydrate promotes interaction with chaperones to help protein folding.