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Science
Systematic study of the natural world based on observation and experimentation.
Biology
The study of living organisms and their interactions with the environment.
Importance of Biology
Helps us understand life processes, medicine, environmental conservation, and evolution.
Characteristics of Life
Organization, metabolism, homeostasis, growth, reproduction, response to stimuli, evolution.
Hierarchical Organization of Life
Atoms → Molecules → Cells → Tissues → Organs → Organ Systems → Organisms → Populations → Communities → Ecosystems → Biosphere.
Scientific Discovery Process
Observation, hypothesis formation, experimentation, analysis, conclusion.
Hypothesis vs. Theory
A hypothesis is a testable explanation; a theory is a well-supported, broad explanation of phenomena.
Variables in an Experiment
Independent (manipulated), dependent (measured), controlled (constant).
Four Themes in Biology
Evolution, structure-function relationships, information flow, energy transformation, interconnections.
Atom Structure
Nucleus (protons, neutrons), electrons in orbitals.
Subatomic Particles
Protons (positive), neutrons (neutral), electrons (negative).
Atomic Number vs. Atomic Mass
Atomic number = protons; Atomic mass = protons + neutrons.
Atoms vs. Isotopes
Isotopes have different numbers of neutrons but the same number of protons.
Importance of Isotopes
Used in medicine (radioactive tracers), dating fossils.
Energy Levels & Electrons
Electrons exist in shells; higher shells have more energy.
Octet Rule
Atoms tend to gain, lose, or share electrons to complete an octet.
Ions vs. Atoms
Ions have gained/lost electrons, making them charged.
Chemical Identity
Determined by the number of protons.
Oxidation & Reduction
Oxidation = loss of electrons; reduction = gain of electrons.
Bond Formation
Elements combine based on valence electrons.
Types of Bonds
Covalent (strong), ionic (transfer electrons), hydrogen (weak attractions).
Electronegativity
An atom’s ability to attract electrons.
Water’s Role in Biology
Universal solvent, high heat capacity, cohesion/adhesion.
Water Ionization
H₂O → H⁺ + OH⁻.
Acids vs. Bases
Acids donate H⁺, bases accept H⁺.
pH Scale
Measures acidity/alkalinity; biological systems maintain homeostasis.
Buffers
Maintain stable pH in biological systems.
Carbon Chemistry
Carbon forms diverse organic molecules.
Four Macromolecules
Carbohydrates, lipids, proteins, nucleic acids.
Elements in Macromolecules
C, H, O, N, P, S.
Examples of Functional Groups
Hydroxyl, carboxyl, amino, phosphate.
Monomers & Polymers
Monomers link to form polymers via dehydration synthesis.
Dehydration vs. Hydrolysis
Dehydration builds molecules; hydrolysis breaks them down.
Carbohydrates
Monosaccharides (glucose), disaccharides (sucrose), polysaccharides (starch). CHO 1:2:1 ratio
Isomers
Same formula, different structure (glucose vs. fructose).
Cellulose & Chitin
Structural polysaccharides.
DNA vs. RNA
DNA = double helix, RNA = single-stranded.
Amino Acid Structure
Amino group, carboxyl group, R group.
Protein Structure
Primary, secondary, tertiary, quaternary.
Saturated vs. Unsaturated Fats
Saturated = no double bonds, solid; unsaturated = double bonds, liquid.
Lipid Functions
Energy storage, membrane structure, signaling.
Cell Size Limitation
Surface area-to-volume ratio constraints.
Plasma Membrane
Composed of phospholipids, proteins, cholesterol.
Cell Theory
All living things are made of cells; cells arise from preexisting cells.
Prokaryotes vs. Eukaryotes
Prokaryotes lack nuclei; eukaryotes have membrane-bound organelles.
Cell Organelles & Functions
Nucleus (DNA storage), mitochondria (ATP production), ribosomes (protein synthesis).
Rough vs. Smooth ER
Rough ER has ribosomes; smooth ER synthesizes lipids.
Lysosomes vs. Peroxisomes
Lysosomes digest; peroxisomes detoxify.
Cytoskeleton Components
Microfilaments, intermediate filaments, microtubules.
Mitochondria & Chloroplasts
Energy-producing organelles.
Endosymbiotic Theory
Mitochondria and chloroplasts originated from bacteria.
Animal vs. Plant Cells
Plants have cell walls, chloroplasts, central vacuoles.
Extracellular Matrix
Provides structural support in animal cells.
Phospholipid Bilayer
Hydrophilic heads, hydrophobic tails.
Membrane Components
Phospholipids, proteins, cholesterol, carbohydrates.
Fluid Mosaic Model
Describes dynamic nature of membranes.
Membrane Proteins
Transport, enzymes, receptors, recognition, adhesion, cytoskeleton attachment.
Passive vs. Active Transport
Passive = no energy; active = ATP required.
Diffusion & Osmosis
Movement of molecules and water.
Tonicity
Hypertonic (water leaves), hypotonic (water enters), isotonic (equilibrium).
Endocytosis & Exocytosis
Transport mechanisms for large molecules.
Selective Permeability
Only specific molecules cross membranes freely.
non polar covalent
equal sharing of electrons (no charge)
polar covalent
unequal sharing of electrons (charge)
adhesion water
water molecules stick to other polar molecules by hydrogen bonding
cohesion
water molecules stick to other molecules by hydrogen bonding
Hydrocabons
Functional groups
specific molecular group that bond to carbon; keep their unique properties, attach to molecule and change how the molecule behaves in reaction
Stereoisomers
same structure different group arrangement
Enantiomers
mirror image molecules
polymer
a large molecule made by linking monomers together
monomer
a small simple chemical unit that can join with each other to form a larger stucture
Monosaccharides, Disaccharides, Polysaccharides
1 sugar molecule (glucose), 2 sugar molecule(lactose), 3 sugar molecule(cellulose and chitin),
Nucleic acids and nucleotides
polymer; monomer
purines
adenine and guanine
pyrimidines
Thymine, Cytosine, and uracil (in RNA)
phosphodiester bond
nucleotides link together forming nucleic acids
ATP (energy)
adenosine triphosphate
Protein Function
Enzyme catalyst, Defense, Transport, Support, Motion, Regulation, Storage
Base pairing
A-T or A-U(RNA), C-G
polypeptide
individual chains that proteins are made of
Peptide bond (in a polypeptide chain)
basic amino group and acidic carboxyl group
Tertiary
final folded shape, for proteins made of only on polypeptide chain
Quaternary structure
arrangement of multiple polypeptide chains (form a complete protein structure)
Motifs
repeated structures found in many proteins
Domains
functional parts of a larger protein
chaperone proteins
help fold proteins correctly, problems with chaperone proteins are linked to diseases (cystic fibrosis)
Denaturation
loses structure by unfolding due to; pH, temperature and ionic concentration of solution
Lipids
don’t dissolve in water; fats oils, waxes, terpenes, steroids and some vitamins
triglycerides
fat one glycerol molecules and three fatty acids
saturated fatty acids
double bonds between carbon atoms, high melted points, from animals
unsaturated fatty acids
no double bonds between carbona atoms, lower melting point, made from plants
phospholipid
glycerol, to fatty acids-non polar tails, phosphate group- polar head
micelles
formed when lipid arrange themselves in water (polar head-outside and nonpolar tails-inside)
Phospholipid bilayer
hydrophilic-outside and hydrophobic-inside
history if cells
first observed using a microscope by Robert Hooke, early studies were conducted by Matthias Schleiden and Theodor Schwann (cell theory)