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what do chemical reactions in the body need?
proper balance of acids and bases
acid-base balance =
homeostasis of H+ ion concentration
what are acids?
substances containing H+ that can be released
what is carbonic acid?
H2CO3
what is a base?
substances that can trap H+
bicarbonate?
HCO3-
what is pH?
expression of H+ ion concentration
acidic on pH scale?
highest 1-6 lowest
neutral on pH scale?
7
base on pH scale?
lowest 8-14 highest
pH of normal blood plasma?
7.35 to 7.45
pH of gastric secretions?
1 to 1.3
pH of pancreatic fluid and bile?
7.8 to 8
pH of urine?
5 to 6
pH of cerebrospinal fluid?
7.28 to 7.32
describe blood pH of 6-7?
death
describe blood pH of 7-7.35?
acidosis
describe blood pH of 7.45-7.8?
alkalosis
describe blood pH of 7.8-9?
death
describe acidosis H+?
excessive H+ ions
describe acidosis bicarbonate?
loss
ph of acidosis?
less than 7.35
describe alkalosis H+?
loss of H+ ions
describe alkalosis bicarbonate?
excess bicarbonate
pH of alkalosis?
greater than 7.45
what does a buffer do?
works to keep the pH normal in the body
what are the three buffer systems?
carbonic acid - sodium bicarbonate buffer, phosphate buffer system, protein buffer system
what is the body's most important buffer system?
carbonic acid - sodium bicarbonate buffer
what is the ratio of bicarbonate to carbonic acid ratio in extracellular fluid?
20:1
what does the carbonic acid - sodium bicarbonate buffer do for the lungs?
regulates the production of carbonic acid
what does the carbonic acid - sodium bicarbonate buffer do for kidneys?
regulates the production of bicarbonate
if you breathe faster than your pH....
increases
where is the phosphate buffer system active?
in the renal tubules
what occurs in the phosphate buffer system?
phosphate binds with acids or bases to alter the pH
what is the protein buffer system do?
plasma proteins and globin combine with H+ to alter pH
what can the respiratory system rapidly do?
can rapidly alter the bodies pH but effects are short term
what is an end product of cellular metabolism?
carbon dioxide
what do the lung excrete?
CO2
if you are trying to get ride of acid what should you do?
breathe deeper and faster
in the assessment of acid base balance what should be assessed and what is measured?
arterial blood gases. measures pH, PaCO2, PaO2, HCO3-
what is there a deficit in in metabolic acidosis?
deficit of bicarbonate
what does metabolic acidosis result from?
from a loss of bicarbonate or excessive acid
metabolic acidosis =
low pH and low HCO3
what are causes of metabolic acidosis?
-diarrhea
-intestinal fistulas
-parenteral nutrition
-excessive intake of acids
-diabetic ketoacidosis
-renal failure
-starvation ketoacidosis
what are the nursing interventions for metabolic acidosis?
correct metabolic deficit. bicarbonate may need to be administered.
what is there an excess in in metabolic alkalosis?
excess of bicarbonate
what may metabolic alkalosis be related to?
acid loss or increased base consumption
metabolic alkalosis =
high pH and high bicarbonate
what are the causes of metabolic alkalosis?
-vomiting
-gastric suction
-hypokalemia
-potassium: wasting diuretics
-alkali ingestion
-renal loss of H+ ions: steroids, diuretics
what are the treatments for metabolic alkalosis?
treatment of underlying disorders. administering fluids. monitoring electrolytes: adequate chloride in the body is needed to excrete bicarbonate
what is their an excess in in respiratory acidosis?
carbonic acid
what does respiratory acidosis result from?
inadequate ventilation
respiratory acidosis =
low pH and high PaCO2
what are the causes of respiratory acidosis?
-acute and chronic respiratory disease
-pulmonary edema
-foreign body aspiration
-overdose of sedative
-cardiac arrest
-inadequate mechanical respiration
-CNS depression
-neuromuscular disorders
what are the nursing interventions for respiratory acidosis?
goal is to improve respiration. pulmonary hygiene. adequate hydration. providing oxygen as needed.
what is their a loss or deficit in in respiratory alkalosis?
loss or deficit of carbonic acid
what does respiratory alkalosis result from?
hyperventilation
respiratory alkalosis =
high pH and low PaCO2
what are causes of respiratory alkalosis?
-hyperventilation
-extreme anxiety
-hypoxemia
-high fever
-early sepsis
-excessive viltration
-CNS lesions affecting the respiratory center
what are the nursing interventions of respiratory alkalosis?
encourage client to breath slowly or breathing into a close system. sedative may be needed
if all three are irregular than...
partially compensated
if two are abnormal and one of them is pH then...
uncompensated
if two are abnormal and neither is pH then...
compensated
what does compensation do?
adjusts the pH
what is partial compensation?
pH remains outside of normal range
what is complete compensation?
pH falls within normal range