3. Spirochetes Serology and VDRL/RPR

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8 Terms

1
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Nontreponemal testing determines the presence of ___ and is based on____

reagin; flocculation

2
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Reagin means that the test looks for antibodies against _______ material when damaged by______

lipid; T. pallidum

3
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flocculation

particles aggregate into larger, loose clusters (flocs) due to chemical or electrostatic interactions

4
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VDRL tests ____and ___ while RPR tests ____only

VDRL: serum and CSF

RPR: serum only

5
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VDRL must be followed _____

exactly

6
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What causes a false positive for VDRL and RPR

  • Causes of acute false (+)

    • Febrile illnesses such as mono, malaria, viral pneumonia cause

  • Causes of chronic false (+)

    • collagen diseases (lupus, RA)

    • Leprosy

    • Treponematoses

  • Pregnancy

  • Aging

7
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what treponemal infections cause a false (+) in VDRL and RPR

yaws and pinta

8
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What tests are used for confirmation of T. pallidum infection

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