VIBS 222: Aflatoxins and Ergot

What does VASOCONSTRICTOR alkaloids cause?

severe numbness

St.John's Fire

gangrene

What does NEUROACTIVE alkaloids cause?

tremors

seizures

hallucinations

What would UTEROTONIC alkaloids cause?

altered uterine contractions

premature labor

spontaneous abortion

What is ERGOTAMINE and CAFFEINE in combination with?

an acute migraine treatment

What is the PRIMARY neuroactive ergot alkaloid?

lysergic acid

What receptor does LSD interact with?

serotonin receptor 5-HT2A

What can HIGH doses of Lysergic Acid result in?

seizures

psychosis

extreme hyperthermia

Is there any FDA approved treatment for LSD?

no

What are some POTENTIAL uses of LSD used for?

cases of severe anxiety and depression

PTSD

What's the connection between ergotism and SALEM WITCH TRIALS?

rye bread was a common food at that time

Why has ergotism become LESS common?

increase usage of fungicides

What MODERN countries still struggle with ergotism?

ethiopia

russia

central asia

Is there a CURE for ergotism?

no: pallative treatment

What are some common MEDICINES to treat ergotism?

vasodilators

activated charcoal

anticoagulants

What does activated charcoal do in treating ERGOTISM?

helps bind remaining toxins to prevent further metabolism