Set 7: Antiviral Agents & Drug Resistance
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7 Terms
Why is it difficult to disrupt viral metabolism without harming the host?
Because viruses use the host's cellular metabolism for replication; disrupting the virus often requires disrupting the host cell
List three modes of action for antiviral drugs
1) Inhibition of entry: Receptor/fusion/un-coating inhibitors
2) Inhibition of nucleic acid synthesis
3) Inhibition of assembly/release
What are the examples of the 1st mode of action for antiviral drugs (Inhibition of entry: Receptor/fusion/un-coating inhibitors)
Enfuvirtide (Fuzeon®), Zanamivir (Relenza®),Oseltamivir (Tamiflu®)
What are the examples of the 2nd mode of action for antiviral drugs (Inhibition of nucleic acid synthesis)
Acyclovir (Zovirax®), Zidovudine (AZT), Remdesivir
What are the examples of the 3rd mode of action for antiviral drugs (Inhibition of viral assembly/release)
Indinavir, saquinavir
What is antimicrobial resistance?
An adaptive response where microorganisms begin to tolerate an amount of drug that would normally be inhibitory.
How does natural selection lead to a drug-resistant population?
A large population has a few naturally resistant cells due to mutation; when exposed to the drug, the sensitive cells die while the resistant ones gain a selective advantage to grow.
