ART- History of IVF

lecture 3

When was the first embryo transfer with rabbits?

1890

When was IVF conceptualized?

In a novel in 1932

Who is the main man developing IVF in rabbits in 1934? Also developed COC?

Dr. Gregory Pincus

When was the first oocyte retrieval and conventional IVF?

1944 by Menkin and Rock

What were some early challenges in IVF?

• access to follicles w/o laparotomy

• culture media (salt solutions, antibodies, patient serum)

• lack of equipment

• timing and control of ovulation

• hyperstimulation difficult to monitor

• luteal phase support poorly understood

• contamination and sterilization

When was discovery of cryoprotectant effects of sperm dicovered?

1949

dry ice (1953-1955)

When was liquid nitrogen first used to preserve sperm?

1960

Who was the first man to attempt to fertilize oocytes in vitro

Robert Edwards - 1965

When was culture media introduced?

1980

When was the worlds first IVF birth?

JULY 25, 1978

Who created first IVF baby?

Robert Edwards, Patrick Steptoe, Jean Purdy

When is national embryology day?

JULY 25- Louise Browns Bday

When was foot-controlled aspiration invented for oocyte retreival?

1981

Introduction of Clomiphene Citrate and hMG inI VF protocol?

1981

When was the worlds first IVF conference?

1981

What are the main historical breakthroughs?

• refinement of culture media

• earlier transfer of embryo

• equipment improvements

• reduced spermatozoa in fertilization dish'

• embryo biopsy

• GIFT to avoid prolonged lab culture

What major technological innovations occurred between 1984-1999?

1. GnRH agonists

2. ultrasound guided embryo transfer

3. ICSI

4. MESA (sperm aspiration)

When did IVF begin in Canada?

1980- IVF clinic in Quebec

1983- IVF baby and Toronto clinic

When was the first ICSI pregnancy?

1992

How did ICSI get invented?

by mistake, as oppsed to SUZI and PZD

Preserved ovarian tissue gives rise to baby in 2004

true

What were the beginning safety risks in children born via IVF

small growth- metabolism, body fat

cancer risk

male infertility in males born after ICSI

What results occurred due to rapid globalization and commercial growth? early 2010

1. more regulation

2. research to clinical service

3. PGT-A

4. large international companies merge

5. legal and ethical challenges

6. routine transport of gametes and embyros

How did patient centric models, innovation and automation change after 2010?

1. egg and sperm banks

2. direct to patient marketing

3. clinics are recipients rather than organizers of gametes

4. shipment of frozen sperm to home

5. non invasive PGT-A

6. vitrification in labs

7. consolidation b/t clinics

8. lab on a chip automation

9. patents secured