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Top national Stressor
Future of the nation (76%)
Stress
A universal, measurable experience that is not inherently pathological. It is a risk factor, not a disorder, it is distinct from anxiety or depression
Bracing
Unnecessary muscular contraction that contributes to tension headaches and physical pain
Trauma
Experiences causing intense physical and psychological stress reactions that are harmful or threatening
ie) combat, assault, natural disaster
Resilience
the ability to âweather adversityâ
Walter cannon
1932
coined the fight or flight response, describing how the sympathetic nervous system primes the body to react to threats
Hans Selye
1936
proposed the general adaptation syndrome(GAS), a non-specific physiological response to demands
Stage 1: Alarm
Stage 2: Resistance
Stage 3: Exhaustion
The Stressor
A stimulus with the potential to trigger a fight or flight response
Can be environmental, psychological, interpersonal
Stress Reactivity
The physiological reaction
Duration of this reaction contributes more to illness than the degree of the reaction
Strain
The physical, psychological, or behavioral consequences of reactivity
ie) tension headaches
Evolutionary Mismatch
Our bodies prepare physiologically for threats that social norms prevent us from acting on
Nine misconception about stress
1) My experience is the same as yours â> one person nightmares is anothers challenge
2) Stress Happens to us
3) Only big things impact us â> daily hassles accumulate
4) We always know when we are stressed
5) Stress is inevitable, live with it â> stressors may be inevitable but the resulting strain is modifiable
6) Relaxation kills productivity â> micro-breaks and recovery sustain concentration and fuel performance
7) Stress and anxiety are the same
8) The same techniques work for everyone
9) You can live in a stress-free world â> change is constant, adaptation is constant
A lack of stress leads to poor performance and boredom
What is Survival Goal:
Brains primary directive is survival, functions ike generating energy, mapping the world, and warning of dangers take precedence over everything else.
Homeostasis
Water cannon
âstanding the sameâ this process maintains vital parameters(like pH, oxygen, and temperature) within narrow, specific ranges.
Allostasis
âstability through changeâ this describes the active process of responding to challenges by operating within broader boundaries
Allostatic load
the wear and tear on the body accumulated when the body is forced to adapt to chronic stress or repeated challenges
Four lobes of brain and functions:
Frontal: planning, decision making, attention, and speech
Temporal: Memory, speech, and auditory processing
Parietal: perception of touch and spatial processing
Occipital: vision and object orientation
Brainstem components and function
Pons: the âbridgeâ regulating sleep and breathing
Medulla Oblongata: regulates heartbeat and blood pressure
Reticular Activating System: regulates arousal
Limbic system
commanded center
thalamus: relay station for sensory data
hypothalamus: the âactivatorâ that triggers the autonomic nervous system
amygdala: handles threat detection and emotional sig
hippocampus: provides context and signals stress based on memory
Low road
fast
sensory stimuli travel from the thalamus directly to the amygdala
high road
slow
stimuli travel from thalamus to sensory cortex
you react before you understand
What are the two hypothalamus pathways
Autonomic nervous system
Endocrine system
Autonomic nervous system response
Sympathetic nervous system: the accelerator, trigger fight or flight
Parasympathetic: the brake, it triggers rest and digest
Adrenal Medulla: releases epinephrine and norepinephrine
Sympathetic nervous system
the accelerator, trigger fight or flight
Parasympathetic
the brake, it triggers rest and digest
Adrenal Medulla
: releases epinephrine and norepinephrine
Hormonal slow trackâ>endocrine system
HPA Axis: Hypothalamus â>CRF/H, Pituitaryâ>ACTH, and Adrenal
Adrenal release glucocorticoids and mineralcortcois which is cortisol and aldosterone
Thyroid system
Thyroid gland releases thyroxine
Pituitary hormones are vasopressin and oxytocin
Cardiovas impact w/ stress
Heart rate and blood pressure are altered by sympathetic nervous system activation and the release of stress hormones
Negative feedback loop
as cortisol levels rise the system shuts itself off
Cortisol Awakening response
cortisol naturally peaks 30-45 min after waking
Trier social stress test
standard research method where participants deliver a speech in front of a not so friendly committee to measure physiological stress response
Dysregulation in PTSD
shows PTSD patients exhibit a âpost-stressor crashâ where cortisol drops significantly below baseline during recovery.
Frontal:
planning, decision making, attention, and speech
Temporal:
Memory, speech, and auditory processing
Parietal:
perception of touch and spatial processing
Occipital
: vision and object orientation
Thalamus:
relay station for sensory data
hypothalamus:
the âactivatorâ that triggers the autonomic nervous system
amygdala:
handles threat detection and emotional sig
hippocampus:
provides context and signals stress based on memory
Pons:
the âbridgeâ regulating sleep and breathing
Medulla Oblongata
regulates heartbeat and blood pressure
Reticular Activating System:
regulates arousal
Psychosomatic disease
Involves both the mind and body, it is often referred to as psychophysiological to emphasize that is it ârealâ diagnosable and manifest physically
College Context
High rates for anxiety and depression
academic impact= 36.8 college students say stress affects academic performance
Leading Killer
heart disease remains the number one cause of death in USA
Risk factor of heart disease
high cholesterol, hypertension, and smokeing
Impact of stress Russek study
research indicates stress and strain in the single highest risk factor for heart disease
general practitioners have sig higher coronary heart disease compared to dermatologist
How does stress impact CVD
increase platelet activation, cytokine production(inflammation), and vasoconstriction
Ischemia
Lack of blood flow to heart
Silent Danger
unlike exercise induced ischemia(that causes chest pain) stress induced ischemia are 3x more likely to suffer a repeat heart attack or death
Amygdala Link
Tawakol
higher resting metabolic activity in the amygdala predicts the development of CVD in advance
amygdala hyperactivityâ>arterial inflammationâ>heart failure
broken heart syndrome
tako tsubo
mimics heart attack w/ massive catecholamines release causing the heart muscle to be âstunnedâ
triggered by severe emotional distress rather than blocked arteries
Acute triggers
catastrophic events are associated with immediate spikes in sudden cardiac death
most common trigger for heart attack is emotional upset
Hippocampus Vulnerability
hippocampus has high density of glucocorticoid receptors â> makes it hghly sensitive to cortisol
cycle of damage
chronic stress leads to elevated cortisolâ>hippocampus atrophyâ>impaired negative feedback loopâ>further cortisol elevation
hostile takeover
under stress the PFC atrophies and loses control while the amygdala expands and drives behavior
stress and memory
encoding: stress during encoding can enhance memory, but stress before impairs it
retrieval: stress prior to a test sig. impairs perfromance
reconsolidating: activated memories become unstable , stress during this phase can alter memory
reversibility: hippocampus volume can recover(neurogenesis) when cortisol normalizes but amygdala is hard to reverse
encoding:
stress during encoding can enhance memory, but stress before impairs it
retrieval:
stress prior to a test sig. impairs perfromance
reconsolidating:
activated memories become unstable , stress during this phase can alter memory
reversibility:
hippocampus volume can recover(neurogenesis) when cortisol normalizes but amygdala is hard to reverse
deep slow breathing
serves as physiological break, by activating the vagus nerve and parasympathetic nervous system to slow heart rate and reduce anxiety
Cohen Study
stressed indiv exposed to the cold virus were 2-3x more likely to get sick
duration matter=severe chronic tress increase chance
immune mech
stress decreases white blood cells
phagocytes
lymphocytes= t cell and b cell
disease prone personality
characterized by depression, hostility and anxiety
cancer prone trait
repressing emotions, self pity, and inability to forgive
cancer resistant traits
optimism, perceived control and expression of emotions