Pain Exam 2: Harrold Skeletal Muscle Relaxants

With 1 exception, all skeletal muscle relaxants act via ___ mechanism and not due to a direct effect on skeletal muscle

CNS

Common ADR of the main skeletal muscle relaxants= ___/___

drowsiness/sedation

Methocarbamol and Carisoprodol MOA

-interrupt neuronal ___ with the spinal cord

-sedation can also reduce skeletal muscle ___

communication, spasms

Baclofen MOA

-___ agonist

-inhibits release of ___ amino acids (Glu and Asp)

GABA, excitatory

Cyclobenzaprine MOA

-inhibits the serotonin ___ receptor in the descending neurons of the spinal cord

5HT2

Cyclobenzaprine also has ___ effects (drowsiness, dry mouth, etc)

anticholinergic

Cyclobenzaprine potentiates NE release. Therefore, do not use with an ____ inhibitor

MAO

Tizanidine MOA

-acts at the ____ receptor in the CNS and decreases the release of ___ amino acids

-inhibits spinal __ neurons

alpha2, excitatory, motor

Tizanidine

-structurally related to clonidine; can cause ____

-can prolong __ interval

-metabolized by CYP1A2

hypotension, QT

Tizanidine

-patients can take med either with food or without food, but must be ____ with 1 plan

consistent