BIOL.113 Lecture 4

The molecular basis of inheritance

Who discovered nucleic acids

Friedrich Miescher

What is a good source of WBC?

Pus. Miescher used bandages from Crimean War soldiers.

Which parts of pus are N rich, and which are acidic P rich?

Proteins. Nucleic acids.

What are nucleic acids made up of?

A 5 carbon sugar, nitrogenous bases, phosphate.

S-form alone (mice)

Mice die

R-form alone (mice)

Mice live

Heat killed s-form (mice)

Mice live

Heat killed s-form + r-form

Mice die

What was the transforming principle?

DNA changing heat killed s-form to r-form

Who took the first photo of DNA

ROSALIND FRANKLIN

What is a bacteriophage

A type of virus composed of DNA and protein

What do bacteriophages do?

Infect bacterial cells