Anti-Depressant Medications

block reabsorption of 5-HT in synapse - thus increase available serotonin

SSRIs

block reuptake of NE & 5-HT, thus increase availability in synapse. 

tricyclic antidepressants

block enzyme (monoamine oxidase) needed to metabolize NE, 5-HT & D - thus increase amount in synapse

MAOIs

includes DNRI, SNRI, serotonin modulators and NE-Serotonin modulators

atypical antidepressant

Paroxetine (paxil) is a…

SSRI

Fluoxetine (Prozac) is a…

SSRI

Sertraline (Zoloft) is a…

SSRI

Flucoxamine (Luvox) is a…

SSRI

Citalopram (Celexa) is a…

SSRI

Venlafaxine (Effexor) is a…

SNRI and atypical antidepressant

Duloxetine (Cymbalta) is a…

SNRI and atypical antidepressant

Desvenlafaxine (Pristiq) is a…

SNRI

Milnacipran (Savella) is a…

SNRI

Mirtazpine (Remeron) is a…

atypical antidepressant

Nefazodone (Serzone) is a…

atypical antidepressant

Bupropion (Wellbutrin) is a…

atypical antidepressant

Trazodone (Desyrel) is a…

atypical antidepressant

Amitriptyline (Elavil) is a…

tricyclic antidepressant

Nortriptyline (Pamelor)

tricyclic antideprssant

Imipramine (Tofranil)

tricyclic antidepressant

Clomipramine (Anafranil)

tricyclic antidepressant

Doxepin (Sinequan)

tricyclic antidepressant

Trimipramine (Surmontil)

tricyclic antidepressant

Desipramine (Norpramin)

tricyclic antidepressants

Phenelzine (Nardil) is a…

MAOI

Tranylcypromine (Parnate) is a…

MAOI

Isocarboxazid (Marplan) is a…

MAOI

Selegiline (Emsam) is a…

MAOI

associated with Tyramine containing foods and other monoamine drugs

hypertensive crisis

aged cheeses, pickled or smoked fish, yeast breads, lunch meats, soy sauce, draft beer, wine, and yogurt all contain…

tyramine

Serotonin Syndrome Mental Status changes:
A___
A__
R___
D___
D___ C____

anxiety
agitation
restlessness
disorientation
difficulty concentrating

Serotonin Syndrome Neuromuscular abnormalities:
M___ t___
T___
H____
M___ R___
U____ M___

muscle twitching
tremors
hyperreflexia
muscle rigidity
uncoordinated movements

Serotonin Syndrome Autonomic Activity:
T___
H___
D___
D___ P___
C___
F___

tachycardia
hypertension
diaphoresis
dilated pupils
chills
fever

other symptoms of serotonin syndrome:
D___
N___
V___

diarrhea
nausea
vomiting

this substance adds to the CNS depression of antidepressant meds and can cause impairment after fewer drinks than in person not taking these meds

alcohol

• Not FDA approved

• Federal law permits unregulated sale of naturally occurring substances

• Marketers must avoid therapeutic claims

• Research studies conducted in US and other countries—not magnitude required by FDA

herbal supplements

True or False: Herbal supplements are real medications and can have therapeutic actions, drug interactions and side effects.

true