maturation sequence of RBCs

pronormoblast

nucleus: round to oval containing 1-2 nucleus

pronormoblast

cytoplasm: dark blue

pronormoblast

cellular activity: hemoglobin production starts, protoporphyrin synthesis are produced, globin production begins

basophilic normoblast

nucleus: chromatin begins to condense, stains deep purple-red

basophilic normoblast

cytoplasm: deeper, richer blue

basophilic normoblast

division: undergoes mitosis

basophilic normoblast

cellular activity: detectable hemoglobin synthesis occurs, many cytopasmic organelles

polychromatic normoblast

nucleus: condensation of chromatin reduces the diameter of nucleus

polychromatic normoblast

cytoplasm: mixture of pink and blue resulting to murky gray-blue

polychromatic normoblast

division: last stage that undergo mitosis

polychromatic normoblast

cellular activity: hemoglobin synthesis increases begins to be visible in the color of cytoplasm

orthochromic normoblast

nucleus is comletely condensed

orthochromic normoblast

cytoplasm: salmon-pink color reflects hemoglobin production

orthochromic normoblast

cellular activity: he nucleus is ejected from the cell, small fragments called Howell-Jolly bodies are left behind if the projection is pinched off before the nucleus is enveloped

reticulocyte

cytoplasm:: salmon-pink color. it is more larger than a mature cell

reticulocyte

location: 1 day in bone marrow or longer then moves into peripheral blood for about 1 day before reaching maturity

reticulocyte

cellular activity: completes the hemoglobin production

erythrocyte

cytoplasm: biconcave disk measuring 7-8 um in diameter,salmon pin - staining with centra pallor 1/3

erythrocyte

location: mature RBCs remain active in the circulation for approximately 120 days. Aging leads to their removal by the spleen.

erythrocyte

cellular activity. delivers oxygen to tissues, releases it and returns to the lung to e reoxygenated