Asfarviridae, Papillomaviridae, Polyomaviridae, Adenoviridae

How would you describe African Swine Fever based on genome?

ds, linear, Icosahedral

Is AFS enveloped/nonenveloped?

enveloped

T/F ASF is seen in Sub-Saharan Africa, China, Russia, and Central Europe (2019) but not US

True

Where are active ASF cases in the world?

Central Europe

There is a chart on slide 6 that he rambled on about for deada** 10 minutes. What are some of the things he talked about?

wildlife outbreaks trail the domestic one

Ro- how infectious a disease is

How FMD came about in Europe- basically talking about if there is a Ro then 100% are susceptible, and if a virus comes in and effects 1-2 people, then everyone becomes infected

(thats what i wrote down may want to go back and watch the soapbox- idk if relevant)

ASF virions are _____, icosahedral structures surrounding a single molecule of ___ double-stranded DNA.

enveloped

linear

T/F ASF virus is stable in the environment over awide range of temperatures and pH values

True

Where can the ASF virus persist for months?

in meat

ASF infectivity may be destroyed by ____ and treating with ____ ____ and ____

heating

lipid solvents and detergents

What class foes ASF virus fall under?

arbovirus

What thing is ASF virus harbored in?

soft-bodied ticks (Ornithodorosgenus)

What are the TWO ways that Ornithodoros ticks transmit the virus?

Transovarian and trans-stadial

T/F Ticks may maintain and transmit the virus topigs for years

True

What is the difference between Transovarian and Transstadial?

Transovarian: transmitted infection through the egg to the larvae

Transstadial: this sh*t has nothing to do w the egg it is just the infected larvae

What are the FOUR ways that pigs are infected by ASF?

material

pig

soft ticks

feed

What are the FIVE ways that boars can get infected?

carcase

material

feed

boar

soft ticks

African swine fever is characterized by ___, ____ in many tissues anda variable mortality rate.

fever

hemorrhages

Subcapsular _____ in the kidneys, petechial and _______ hemorrhages onserosal surfaces, and edema of the lungs and hydrothorax result from disseminated intravascular coagulation, endothelial damage and destruction of _____.

petechiation

ecchymotic

megakaryocytes

What are the THREE differential for ASF?

classical swine fever

erysipelas

septicemic salmonellosis

T/F The virulence of diverse strains is variable

True

Can some naïve populations have 100% mortality?

well duh

Ingestion of ____ ____ from infected warthogs or domestic pigs is a major method of transmission for ASF

uncooked meat

Feeding uncooked swill is an important mechanism of spread of ASF ______, with outbreaks often starting in herds close to ___ and _____.

internationally

airports

ports

Observation of what aids in the diagnosis of ASF?

hemadsorption

What are the TWO ways that you can do to control ASF?

biosecurity and institution of eradication policies in the face of an outbreak

T/F DNA and RNA mutate at the same rate

False, RNA mutate faster

How would you describe the genome of Papillomaviridae?

ds, circular, Icosahedral

Is Papillomaviridae enveloped/nonenveloped?

Nonenveloped

T/F Papillomaviruses are everywhere

True

How is Papillomaviruses transmitted? Where is it typically seen?

through direct contact

face, ears

How do you diagnose Papillomaviruses?

Clinical appearance

Papillomavirus synergism is seen with the ingestion of what?

bracken fern (toxicity)

Bracken fern maytransform GI papillomas to what?

squamous cell carcinomas

What is a locally invasive fibroblastic skin tumor?

Equine Sarcoid

Budgerigar Fledgling Disease Virus is what class of virus?

POLYOMAVIRIDAE

How would you describe the genome of Budgerigar Fledgling Disease Virus?

ds, circular, Icosahedral

Is Budgerigar Fledgling Disease Virus enveloped or nonenveloped?

Nonenveloped

____ Polyomavirus associated with Neuroglial Tumors in ____- in Western US:Histology and detection of RacPyV genome and TAg mRNA by in situ hybridization.

Raccoon

Racoon

(now wtf)

T/F Raccoons can get canine distemper

True

What is an example of ADENOVIRIDAE?

Infectious Canine Hepatitis Virus

What is different about ADENOVIRIDAE?

they are non enveloped but survive in the environment for a very long time

How would you describe the genome of ADENOVIRIDAE?

ds, linear, Icosahedral

Due to ADENOVIRIDAE being nonenveloped, what does this mean?

resistant to environmental inactivation

T/F Enveloped virus are stable in the environment, relatively resistant to disinfection, and stable in the GI tract

False, Nonenveloped

T/F Nonenveloped can withstand low pH, bile acids and proteolytic enzymes

True

What are the THREE overlapping syndromes of Canine InfectiousHepatitis (CAV1)

Peracute Disease & Death

Acute Disease

Mild Disease

What is the ONE major thing that differentiates Canine Infectious Hepatitis (CAV1) from PARVO?

icterus

What is the virus strain in the Kennel Cough vaccine?

Canine adenovirus 2

How is Kennel Cough transmitted?

shed in feces and saliva