5. Epigenetic Control of Gene Expression + Evaluating Data on Phenotypes.
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10 Terms
What does epigenetic control do?
Determines whether a gene is switched on or off/ expressed or not.
Read first 2 paragraphs on page 466 Biology CGP book for summary.
.
List two chemical markers
methyl groups
acetyl groups
Where do methyl groups attatch to
CpG site where cytosine and guanine base are next to each other in the DNA.
The effects of increased methylation of DNA on gene expression.
Increased methylation changes the DNA structure so that the transcriptional machinery can’t interact with the gene - so the gene is not expressed.
what are histones
proteins that DNA wraps around to form chromatic, which makes up chromosomes.
what is acetylation
addition or removal of acetyl groups
the effects of acetylation on acetyl groups
when histones are acetylated, chromatin is less condensed, so transcriptional machinery can access the DNA, allowing genes to be transcribed.
what enzymes are responsible for removing acetyl groups
deacetylase (HDAC)
Read development of disease = page 467 to page 470.
Note 
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