Potassium-Sparing Diuretics

potassium-sparing diuretic

they are weaker than thiazides and loop diuretics; hence they are used as mild diuretics or in combination with another diuretic

hyperkalemia

this results to _______ when a potassium supplement is taken with a potassium-sparing diuretic

5 mEq/L

NURSING CONSIDERATIONS: restrict foods high in potassium if the serum potassium level is greater than _______

distal tubule and collecting duct

site of action of potassium-sparing diuretics

aldosterone

potassium-sparing interfere with the Na-K pump controlled by _______

spironolactone

the first potassium-sparing diuretic, discovered in 1958

cardiac disorders

spironolactone is prescribed by cardiologists for pateints with ________ due to its potassium-retaining effect

myocardial fibrosis

because of its potassium retaining effect, it results to regular heart rate and decreased possibility of _______

amiloride and eplerenone

potassium-sparing diuretics that are effective as antihypertensive agents

triamterene

potassium-sparing diuretic useful in the treatment of edema caused by heart failure or cirrhosis of the liver

Aldactone

generic name: spironolactone

Midamor

generic name: amiloride

Dyrenium

generic name: triamterene

Inspra

generic name: eplerenone

ACE inhibitors, ARBs

potassium-sparing diuretics should not be used with _____ and ______ because both drugs can increase serum potassium levels

serum potassium levels

potassium-sparing diuretics should not be used with ACE inhibitors and ARBs because both drugs can increase ____________

potassium-wasting diuretic

they are usually combined with a _____ to reduce body fluid

hydrochlorothiazide, loop diuretics

commonly combined potassium-wasting diuretic

Aldactazide

common combination: spironolactone + hydrochlorothiazide

Moduretic

common combination: amiloride + hydrochlorothiazide

Dyazide, Maxzide

common combination: triamterene + hydrocrhlorothiazide

sodium

potassium-sparing diuretics cause a loss of _____ while promoting potassium retention

aldosterone antagonist

spironolactone acts as an _________ (they block aldosterone in the tubule)

spironolactone

drug of choice for treating hyperaldosteronism

hyperkalemia

main side/adverse effect of potassium-wasting diuretic

ACE inhibitors

NURSING CONSIDERATION: avoid combining potassium-sparing diuretics with _____ to prevent severe hyperkalemia

salicylates

DRUG INTERACTIONS: diuretic effect decreases if potassium-sparing diuretics are combined with _________