Calcium Channel Blockers Pharmacology

What are the roles of calcium

Contractile 

Electrical 

Cellular 

What do Sa nodes do

regulates pacemaker

What are the ways that calcium moves and stores

Receptor operated channels

Na/Ca exchange 

Leak Process

Voltage Dependent 

What is the main way calcium goes into the vessels

Voltage gated ion channels

What is the IV Calcium Channel Blocker

Clevidipine

What are the non dihydropyridine Calcium Channel Blockers

Verapamil

Dilitiazem

What is the benefit of Dihydroperidine

Peripheral Vasodilation 

What is the advanrage of Non Dip CCB

SA and AV node depressant effects

Which Voltage Sensitive Channel is the most active

L type

What is the danger of Dihydropyridines

Vascular shock 

What is the danger of Non DIP

Bradycardia and AV Block and cardiac arrest liability

What is Nifedepine

Arteriolar Vasodilator

What is Amlodipine 

1st gen 

Long ½ life 

Hypertension

What are some side effects of Amlodipine

Syncopy

Induce Angina and MI

What is the MOA of Dilitiazem

Decreases peripheral resistance and afterload

Reduce heart rate

Benefits atrial and nodal tachycardias

MOA of Verapamil

Reduces BP by dilating peripheral blood vessels and negative inotropic effects inhiibit sympathetic reflexes that elevate BP

What is Cleviprex

DiHydropyridine

IV calcium Channel Blocker

Racemic mixture

Selective for smooth muscle